HitPredict

Interactor 1: TLX3 (O43711)
T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2)
Gene: TLX3

Interactor 2: TFAM (Q00059)
Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)
Gene: TFAM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 291 Hs			1 246
+	Hs
		725241 TLX1_HUMAN (1-290): 1.1e-38: 140: 53.98		TFAM_HUMAN (1-246): 2.64e-63: 199: 100.00
+	Hs
		225120 TLX3_HUMAN (1-291): 1.22e-58: 190: 100.00		HM20A_HUMAN (45-146): 9.12e-25: 102: 19.61
+	Hs
		725325 TLX1_HUMAN (1-290): 1.1e-38: 140: 53.98		HM20A_HUMAN (45-146): 9.12e-25: 102: 19.61
+	Dm
		1014335 UBX_DROME (27-230): 2.28e-30: 119: 22.49		Q86BR8_DROME (47-232): 7.71e-31: 117: 30.16
+	Hs
		662284 PAX7_HUMAN (34-284): 3.11e-34: 131: 16.41		HM20A_HUMAN (45-146): 9.12e-25: 102: 19.61
+	Hs
		184762 SHOX_HUMAN (112-257): 4.85e-33: 124: 19.86		SOX6_HUMAN (49-160): 3.08e-26: 108: 12.82
+	Hs
		226605 TLX2_HUMAN (4-290): 2.38e-35: 130: 58.89		HM20A_HUMAN (45-146): 9.12e-25: 102: 19.61
+	Hs
		184761 SHOX_HUMAN (112-257): 4.85e-33: 124: 19.86		SOX5_HUMAN (49-150): 3.73e-24: 102: 12.75
+	Hs
		685116 PAX6_HUMAN (36-289): 3.28e-30: 119: 16.73		SOX5_HUMAN (49-150): 3.73e-24: 102: 12.75
+	Hs
		634885 HXA5_HUMAN (31-237): 5.73e-36: 131: 19.27		SOX17_HUMAN (119-233): 5.01e-19: 87.1: 14.29
+	Dm
		1014407 UBX_DROME (27-230): 2.28e-30: 119: 22.49		Q9VUD3_DROME (144-228): 3.03e-21: 94.1: 20.23
+	Dm
		121513 UBX_DROME (27-230): 2.28e-30: 119: 22.49		M9PFG6_DROME (123-233): 1.99e-20: 91: 14.78
+	Dm
		120234 UBX_DROME (27-230): 2.28e-30: 119: 22.49		M9PCZ7_DROME (147-224): 4.48e-20: 90.6: 25.61
+	Hs
		662313 PAX3_HUMAN (34-288): 4.33e-32: 125: 17.11		SOX10_HUMAN (140-242): 5.12e-17: 81.4: 15.32
+	Hs
		481116 HXD3_HUMAN (98-276): 3.55e-34: 130: 28.57		HMGB1_HUMAN (27-128): 2.6e-15: 74: 15.69
+	Hs
		186620 PAX6_HUMAN (36-289): 3.28e-30: 119: 16.73		HMGB3_HUMAN (46-136): 4.08e-18: 81.4: 21.98
+	Hs
		685121 PAX6_HUMAN (36-289): 3.28e-30: 119: 16.73		SOX9_HUMAN (140-241): 6.32e-16: 78.3: 15.09
+	Hs
		481050 HXC6_HUMAN (127-224): 8.42e-32: 119: 31.63		HMGB1_HUMAN (27-128): 2.6e-15: 74: 15.69
+	Hs
		1437255 NANOG_HUMAN (102-281): 5.54e-34: 127: 29.47		SOX21_HUMAN (153-235): 8.66e-11: 62.5: 21.84
+	Dm
		1014420 UBX_DROME (27-230): 2.28e-30: 119: 22.49		Q9W2K8_DROME (46-188): 2.64e-10: 61.7: 23.08