HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CALR (P27797)
Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)
Gene: CALR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

The method score is based on:

Property	Details
Experiments	35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol and 8 others more... GO:0008270 - zinc ion binding GO:0010628 - positive regulation of gene expression GO:0031625 - ubiquitin protein ligase binding GO:0036503 - ERAD pathway GO:0042981 - regulation of apoptotic process GO:0048471 - perinuclear region of cytoplasm GO:0050821 - protein stabilization GO:0051087 - protein-folding chaperone binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	465
Hs

1	417

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024