HitPredict

Interactor 1: SOX2 (P48432)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: Q9QX99 (Q9QX99)
T-cell leukemia, homeobox 1 (Transcription factor)
Gene: Tlx1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	22194602
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 319 Mm			1 333
+	Hs
		725306 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		TLX1_HUMAN (1-333): 1.5e-60: 198: 93.39
+	Hs
		872756 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		NANOG_HUMAN (141-319): 6.11e-39: 141: 26.46
+	Hs
		872735 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		ALX4_HUMAN (11-331): 2.47e-33: 128: 17.68
+	Mm
		478349 Q60I23_MOUSE (1-319): 5.92e-68: 216: 98.43		HXA5_MOUSE (16-279): 5.55e-32: 122: 21.51
+	Hs
		604795 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		HXB9_HUMAN (15-269): 1.1e-32: 123: 18.82
+	Mm
		204336 SOX2_MOUSE (1-319): 1.16e-66: 213: 100.00		ALX4_MOUSE (11-331): 3.56e-31: 122: 16.27
+	Hs
		634834 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		HXA5_HUMAN (16-279): 1.48e-31: 121: 21.15
+	Hs
		872218 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		PO5F1_HUMAN (39-330): 9.28e-31: 121: 16.33
+	Hs
		225087 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		TLX3_HUMAN (11-328): 2.13e-32: 123: 48.11
+	Hs
		604850 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		HXB9_HUMAN (15-269): 1.1e-32: 123: 18.82
+	Hs
		634873 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		HXA5_HUMAN (16-279): 1.48e-31: 121: 21.15
+	Hs
		1401418 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		VSX1_HUMAN (41-291): 2.21e-30: 120: 21.91
+	Hs
		226588 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		TLX2_HUMAN (66-330): 1.24e-30: 118: 51.96
+	Hs
		253024 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		LMX1B_HUMAN (162-333): 2.31e-29: 118: 18.04
+	Hs
		184761 SOX5_HUMAN (17-129): 1.87e-39: 149: 40.71		SHOX_HUMAN (188-295): 1.33e-33: 127: 26.85
+	Dm
		121513 M9PFG6_DROME (31-253): 2.05e-39: 145: 46.09		UBX_DROME (82-268): 1e-32: 126: 23.26
+	Hs
		776039 SOX5_HUMAN (17-129): 1.87e-39: 149: 40.71		GSC_HUMAN (19-288): 9.69e-31: 118: 23.99
+	Hs
		239920 SOX15_HUMAN (13-177): 1.88e-39: 140: 48.50		HXB9_HUMAN (15-269): 1.1e-32: 123: 18.82
+	Hs
		225120 HM20A_HUMAN (1-278): 2.4e-37: 138: 13.17		TLX3_HUMAN (11-328): 2.13e-32: 123: 48.11
+	Hs
		942479 SOX13_HUMAN (35-129): 1.58e-37: 143: 43.16		GSC_HUMAN (19-288): 9.69e-31: 118: 23.99