HitPredict

Interactor 1: KRT86 (O43790)
Keratin, type II cuticular Hb6 (Hair keratin K2.11) (Keratin-86) (K86) (Type II hair keratin Hb6) (Type-II keratin Kb26)
Gene: KRT86

Interactor 2: EPIPL (P58107)
Epiplakin (450 kDa epidermal antigen)
Gene: EPPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045095 - keratin filament GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 486 Hs			1 5088
+	Hs
		475750 K2C7_HUMAN (22-461): 1.66e-160: 464: 50.91		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		437133 K2C8_HUMAN (78-443): 1.22e-116: 353: 56.83		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		945815 K2C73_HUMAN (11-420): 1.49e-88: 282: 50.24		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		341753 K2C75_HUMAN (6-420): 2.52e-82: 266: 49.01		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		945869 KRT82_HUMAN (4-433): 1.34e-82: 266: 60.59		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		945796 K2C72_HUMAN (21-486): 2.46e-76: 250: 43.59		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		945793 K1H2_HUMAN (4-417): 3.49e-68: 226: 24.16		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		551544 K2C3_HUMAN (78-421): 3.89e-63: 218: 57.47		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		475760 K2C7_HUMAN (22-461): 1.66e-160: 464: 50.91		PLEC_HUMAN (1149-4489): 2.54e-72: 275: 17.38
+	Hs
		227225 KRT86_HUMAN (1-486): 3.61e-117: 354: 100.00		PLEC_HUMAN (1149-4489): 2.54e-72: 275: 17.38
+	Hs
		437181 K2C8_HUMAN (78-443): 1.22e-116: 353: 56.83		PLEC_HUMAN (1149-4489): 2.54e-72: 275: 17.38
+	Hs
		876475 K2C6C_HUMAN (71-420): 2.67e-71: 238: 57.96		PLEC_HUMAN (1149-4489): 2.54e-72: 275: 17.38
+	Hs
		407381 K2C1_HUMAN (75-431): 4.17e-124: 377: 54.44		DESP_HUMAN (2873-5087): 3.07e-30: 135: 10.82
+	Hs
		437082 K2C8_HUMAN (78-443): 1.22e-116: 353: 56.83		DESP_HUMAN (2873-5087): 3.07e-30: 135: 10.82
+	Hs
		248655 K2C8_HUMAN (78-443): 1.22e-116: 353: 56.83		PEPL_HUMAN (2575-3932): 2.77e-26: 122: 10.40
+	Hs
		437271 K2C8_HUMAN (78-443): 1.22e-116: 353: 56.83		NIN_HUMAN (2307-3806): 1.17e-14: 84: 9.19
+	Hs
		437068 K2C8_HUMAN (78-443): 1.22e-116: 353: 56.83		DMD_HUMAN (1909-3327): 6.26e-09: 65.1: 11.08
+	Hs
		566326 K2C5_HUMAN (71-420): 5.94e-71: 238: 59.09		DESP_HUMAN (2873-5087): 3.07e-30: 135: 10.82
+	Hs
		385233 K2C6A_HUMAN (71-420): 4.05e-70: 235: 58.24		DESP_HUMAN (2873-5087): 3.07e-30: 135: 10.82
+	Hs
		566422 K2C5_HUMAN (71-420): 5.94e-71: 238: 59.09		NIN_HUMAN (2307-3806): 1.17e-14: 84: 9.19