HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: SUMO1 (P63165)
Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)
Gene: SUMO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.972

The method score is based on:

Property Details
Experiments 32296183, 21988832, 25416956, 14609633, 19217413, 16524884, 16204249, unassigned1304
Identification Methods two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid, nuclear magnetic resonance, isothermal titration calorimetry
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Rad60-SLD~zf-MIZ
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016605 - PML body
GO:0016607 - nuclear speck
GO:0016925 - protein sumoylation
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 621
Hs

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Last updated: 15 Jul 2024