HitPredict

Interactor 1: SF3B1 (O75533)
Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)
Gene: SF3B1

Interactor 2: PP4C (P60510)
Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X)
Gene: PPP4C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1304 Hs			1 307
+	Hs
		285849 SF3B1_HUMAN (1-1304): 0: 1351: 100.00		PP1A_HUMAN (2-304): 0: 517: 43.89
+	Hs
		718094 2AAB_HUMAN (811-1268): 2.9e-56: 208: 14.94		PP4C_HUMAN (1-307): 0: 537: 100.00
+	Dm
		661918 2AAA_DROME (811-1268): 2.24e-59: 217: 13.48		PP2A_DROME (2-307): 0: 524: 64.05
+	Hs
		718098 2AAB_HUMAN (811-1268): 2.9e-56: 208: 14.94		PP2AB_HUMAN (6-307): 0: 525: 65.23
+	Hs
		718101 2AAB_HUMAN (811-1268): 2.9e-56: 208: 14.94		PP2AA_HUMAN (6-307): 0: 524: 65.89
+	Hs
		717747 2AAA_HUMAN (496-1043): 1.49e-28: 124: 14.15		PP4C_HUMAN (1-307): 0: 537: 100.00
+	Hs
		717759 2AAA_HUMAN (496-1043): 1.49e-28: 124: 14.15		PP2AB_HUMAN (6-307): 0: 525: 65.23
+	Mm
		977639 2AAA_MOUSE (496-1043): 2.23e-28: 124: 14.15		PP2AB_MOUSE (6-307): 0: 525: 65.23
+	Hs
		717766 2AAA_HUMAN (496-1043): 1.49e-28: 124: 14.15		PP2AA_HUMAN (6-307): 0: 524: 65.89
+	Hs
		91606 C9J9C1_HUMAN (510-1043): 4.18e-28: 123: 13.97		PP2AB_HUMAN (6-307): 0: 525: 65.23
+	Mm
		994011 2AAA_MOUSE (496-1043): 2.23e-28: 124: 14.15		PP2AA_MOUSE (6-307): 0: 524: 65.89
+	Hs
		91607 C9J9C1_HUMAN (510-1043): 4.18e-28: 123: 13.97		PP2AA_HUMAN (6-307): 0: 524: 65.89
+	Sp
		661366 2AAA_SCHPO (496-1153): 1.83e-30: 130: 15.94		PP2A2_SCHPO (2-307): 0: 510: 63.40
+	Sp
		661356 2AAA_SCHPO (496-1153): 1.83e-30: 130: 15.94		PP2A1_SCHPO (2-307): 3.58e-154: 435: 63.19
+	Sc
		660776 2AAA_YEAST (814-1273): 2.34e-30: 130: 12.18		PP2A1_YEAST (4-307): 1.51e-148: 423: 60.98
+	Hs
		143674 GCN1_HUMAN (484-1290): 6.75e-28: 125: 15.76		PPP6_HUMAN (6-307): 1.54e-148: 420: 61.92