HitPredict

Interactor 1: BCAR3 (O75815)
Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)
Gene: BCAR3

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0007173 - epidermal growth factor receptor signaling pathway GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 825 Hs			1 694
+	Hs
		1106501 SH23A_HUMAN (141-817): 0: 534: 34.51		GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00
+	Hs
		463085 YES_HUMAN (10-496): 4.86e-71: 245: 11.59		GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00
+	Mm
		431376 SRC_MOUSE (33-496): 1.48e-71: 246: 12.75		GAB1_MOUSE (1-694): 3.64e-172: 510: 89.93
+	Hs
		557285 SRC_HUMAN (26-496): 5.87e-70: 242: 11.62		GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00
+	Hs
		599288 PLCG2_HUMAN (8-466): 7.47e-62: 229: 12.63		GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00
+	Hs
		463507 LYN_HUMAN (43-496): 1.88e-59: 212: 10.00		GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00
+	Hs
		473414 HCK_HUMAN (31-488): 3.27e-59: 212: 10.85		GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00
+	Hs
		584536 VAV_HUMAN (10-317): 1.2e-56: 210: 16.28		GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00
+	Hs
		902834 BLK_HUMAN (53-496): 5.11e-56: 202: 13.07		GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00
+	Hs
		557534 SRC_HUMAN (26-496): 5.87e-70: 242: 11.62		GAB2_HUMAN (3-691): 1.85e-144: 438: 38.73
+	Hs
		599312 PLCG2_HUMAN (8-466): 7.47e-62: 229: 12.63		GAB2_HUMAN (3-691): 1.85e-144: 438: 38.73
+	Hs
		463850 LYN_HUMAN (43-496): 1.88e-59: 212: 10.00		GAB2_HUMAN (3-691): 1.85e-144: 438: 38.73
+	Mm
		683116 LYN_MOUSE (43-496): 1.02e-59: 213: 10.00		GAB2_MOUSE (3-691): 3.12e-131: 404: 38.05
+	Hs
		557406 SRC_HUMAN (26-496): 5.87e-70: 242: 11.62		GAB3_HUMAN (1-683): 9.25e-96: 309: 28.39
+	Hs
		440651 FYN_HUMAN (12-496): 2.75e-67: 234: 9.93		GAB3_HUMAN (1-683): 9.25e-96: 309: 28.39
+	Hs
		463682 LYN_HUMAN (43-496): 1.88e-59: 212: 10.00		GAB3_HUMAN (1-683): 9.25e-96: 309: 28.39
+	Hs
		463129 YES_HUMAN (10-496): 4.86e-71: 245: 11.59		PKHA7_HUMAN (5-485): 2.19e-62: 227: 11.88
+	Hs
		463775 LYN_HUMAN (43-496): 1.88e-59: 212: 10.00		PKHA5_HUMAN (5-476): 3.42e-64: 232: 12.37
+	Hs
		463588 LYN_HUMAN (43-496): 1.88e-59: 212: 10.00		PKHA7_HUMAN (5-485): 2.19e-62: 227: 11.88
+	Hs
		463776 LYN_HUMAN (43-496): 1.88e-59: 212: 10.00		PKHA1_HUMAN (6-156): 1.01e-32: 132: 25.49