HitPredict

Interactor 1: ARI2 (O95376)
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein)
Gene: ARIH2

Interactor 2: IL4RA (P24394)
Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
Gene: IL4R

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	16169070
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 493 Hs			1 825
+	Hs
		312672 ARI2_HUMAN (1-493): 0: 546: 100.00		OGFR_HUMAN (292-679): 4.46e-10: 65.5: 13.33
+	Hs
		227885 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		MICA3_HUMAN (343-708): 4.37e-13: 75.5: 16.91
+	Mm
		88466 PRKN_MOUSE (113-330): 3.85e-52: 184: 23.72		D3Z656_MOUSE (280-650): 1.68e-11: 70.2: 11.82
+	Hs
		227838 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		SRCAP_HUMAN (357-819): 3.55e-11: 69.3: 11.78
+	Hs
		228928 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		OGFR_HUMAN (292-679): 4.46e-10: 65.5: 13.33
+	Hs
		228101 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		KMT2C_HUMAN (259-810): 2.56e-09: 63.3: 10.59
+	Hs
		229228 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		PCLO_HUMAN (260-786): 3.63e-09: 62.9: 11.19