HitPredict

Interactor 1: TRI37 (O94972)
E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)
Gene: TRIM37

Interactor 2: K2C74 (Q7RTS7)
Keratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37)
Gene: KRT74

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33194618
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 964 Hs			1 529
+	Hs
		323083 TRI37_HUMAN (1-964): 0: 1226: 100.00		K2C1_HUMAN (105-471): 1.47e-162: 477: 66.21
+	Hs
		323212 TRI37_HUMAN (1-964): 0: 1226: 100.00		K22E_HUMAN (112-456): 3.27e-150: 446: 67.54
+	Hs
		323097 TRI37_HUMAN (1-964): 0: 1226: 100.00		K2C8_HUMAN (112-480): 3.64e-130: 389: 58.81
+	Hs
		323117 TRI37_HUMAN (1-964): 0: 1226: 100.00		K2C7_HUMAN (45-467): 1.89e-130: 389: 56.50
+	Hs
		323144 TRI37_HUMAN (1-964): 0: 1226: 100.00		K2C5_HUMAN (1-456): 1.3e-82: 270: 57.85
+	Hs
		323082 TRI37_HUMAN (1-964): 0: 1226: 100.00		K2C6B_HUMAN (2-472): 6.1e-81: 264: 56.80
+	Hs
		323072 TRI37_HUMAN (1-964): 0: 1226: 100.00		K2C6A_HUMAN (2-472): 7.02e-77: 254: 57.00
+	Hs
		407386 RO52_HUMAN (1-459): 1.53e-75: 257: 15.61		K2C1_HUMAN (105-471): 1.47e-162: 477: 66.21
+	Hs
		407380 TRI27_HUMAN (1-458): 3.63e-69: 241: 14.78		K2C1_HUMAN (105-471): 1.47e-162: 477: 66.21
+	Hs
		407477 TRI67_HUMAN (10-367): 1e-58: 218: 16.27		K2C1_HUMAN (105-471): 1.47e-162: 477: 66.21
+	Hs
		551533 TRI27_HUMAN (1-458): 3.63e-69: 241: 14.78		K2C3_HUMAN (88-458): 4.9e-147: 437: 66.49
+	Hs
		777501 TRI67_HUMAN (10-367): 1e-58: 218: 16.27		K22E_HUMAN (112-456): 3.27e-150: 446: 67.54
+	Hs
		341734 TRI27_HUMAN (1-458): 3.63e-69: 241: 14.78		K2C75_HUMAN (1-465): 9.97e-96: 303: 58.49
+	Hs
		1254394 TRI67_HUMAN (10-367): 1e-58: 218: 16.27		K2C74_HUMAN (1-529): 1.07e-92: 294: 100.00
+	Hs
		566424 TRI58_HUMAN (1-457): 1.32e-67: 236: 16.00		K2C5_HUMAN (1-456): 1.3e-82: 270: 57.85
+	Hs
		566407 TRI67_HUMAN (10-367): 1e-58: 218: 16.27		K2C5_HUMAN (1-456): 1.3e-82: 270: 57.85
+	Hs
		407309 TRI67_HUMAN (10-367): 1e-58: 218: 16.27		K2C6B_HUMAN (2-472): 6.1e-81: 264: 56.80
+	Hs
		876483 TRI67_HUMAN (10-367): 1e-58: 218: 16.27		K2C6C_HUMAN (2-472): 1.24e-80: 264: 56.80
+	Hs
		571930 TRI27_HUMAN (1-458): 3.63e-69: 241: 14.78		K22O_HUMAN (1-467): 4.21e-69: 235: 57.06
+	Hs
		385290 TRI67_HUMAN (10-367): 1e-58: 218: 16.27		K2C6A_HUMAN (2-472): 7.02e-77: 254: 57.00