HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 839
+	Hs
		1081533 MINK1_HUMAN (1-1239): 0: 1120: 59.29		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		1081641 TNIK_HUMAN (1-1239): 0: 1101: 60.56		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		324713 M4K4_HUMAN (1-1239): 0: 1227: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		324728 M4K4_HUMAN (1-1239): 0: 1227: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		324739 M4K4_HUMAN (1-1239): 0: 1227: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		1083868 MINK1_HUMAN (1-1239): 0: 1120: 59.29		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Mm
		546291 TNIK_MOUSE (1-1239): 0: 1120: 62.43		NTRK2_MOUSE (6-839): 0: 555: 53.29
+	Hs
		508100 MINK1_HUMAN (1-1239): 0: 1120: 59.29		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		508260 TNIK_HUMAN (1-1239): 0: 1101: 60.56		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		608181 TNIK_HUMAN (1-1239): 0: 1101: 60.56		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		324720 M4K4_HUMAN (1-1239): 0: 1227: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		968512 TNIK_HUMAN (1-1239): 0: 1101: 60.56		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Mm
		956967 M4K4_MOUSE (1-1239): 0: 1142: 88.17		PTK7_MOUSE (212-394): 3.12e-10: 66.3: 17.35
+	Mm
		1206831 MINK1_MOUSE (1-1239): 0: 1124: 59.30		PTK7_MOUSE (212-394): 3.12e-10: 66.3: 17.35
+	Hs
		647902 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Hs
		384307 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		385052 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		507867 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		647876 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		411417 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43