HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: UB2J1 (Q9Y385)
Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)
Gene: UBE2J1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	37409633
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2799 Hs			1 318
+	Hs
		325776 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D2_HUMAN (10-156): 6.77e-70: 215: 28.00
+	Hs
		326110 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D4_HUMAN (10-156): 6.34e-70: 215: 28.00
+	Hs
		325740 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D1_HUMAN (10-156): 1.34e-69: 214: 30.00
+	Hs
		325765 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D3_HUMAN (10-156): 2.03e-68: 211: 28.00
+	Hs
		325741 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E1_HUMAN (1-155): 4.54e-64: 202: 28.48
+	Hs
		325968 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E3_HUMAN (2-155): 1.58e-62: 199: 26.75
+	Hs
		325987 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E2_HUMAN (2-155): 4.94e-62: 197: 27.39
+	Hs
		325726 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UBE2A_HUMAN (7-154): 9.7e-61: 192: 21.85
+	Hs
		325780 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UBE2B_HUMAN (7-146): 1.16e-59: 189: 23.08
+	Hs
		982221 HECW1_HUMAN (2170-2798): 2.45e-168: 568: 20.31		UB2D2_HUMAN (10-156): 6.77e-70: 215: 28.00
+	Hs
		906687 HECW1_HUMAN (2170-2798): 2.45e-168: 568: 20.31		UB2D1_HUMAN (10-156): 1.34e-69: 214: 30.00
+	Hs
		957112 HECW1_HUMAN (2170-2798): 2.45e-168: 568: 20.31		UB2D3_HUMAN (10-156): 2.03e-68: 211: 28.00
+	Hs
		1260701 HECW1_HUMAN (2170-2798): 2.45e-168: 568: 20.31		UB2J2_HUMAN (1-150): 3.35e-63: 202: 39.87
+	Hs
		982349 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		UB2D2_HUMAN (10-156): 6.77e-70: 215: 28.00
+	Hs
		957222 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		UB2D3_HUMAN (10-156): 2.03e-68: 211: 28.00
+	Hs
		982329 SMUF1_HUMAN (2357-2796): 2.48e-141: 463: 21.18		UB2D2_HUMAN (10-156): 6.77e-70: 215: 28.00
+	Hs
		906789 SMUF1_HUMAN (2357-2796): 2.48e-141: 463: 21.18		UB2D1_HUMAN (10-156): 1.34e-69: 214: 30.00
+	Hs
		957206 SMUF1_HUMAN (2357-2796): 2.48e-141: 463: 21.18		UB2D3_HUMAN (10-156): 2.03e-68: 211: 28.00
+	Hs
		906788 SMUF2_HUMAN (2405-2796): 3.91e-134: 442: 22.36		UB2D1_HUMAN (10-156): 1.34e-69: 214: 30.00
+	Hs
		970227 SMUF1_HUMAN (2357-2796): 2.48e-141: 463: 21.18		UB2G1_HUMAN (15-148): 2.06e-56: 182: 25.83