HitPredict

Interactor 1: M3K6 (O95382)
Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)
Gene: MAP3K6

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.924

The method score is based on:

Property Details
Experiments 9875215, 25852190, 11689443, 19935702, 17210579
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ASK_PH~ASK_PH, ASK_PH~MAP3K_TRAF_bd, ASK_PH~Pkinase, DRHyd-ASK~MAP3K_TRAF_bd, MAP3K_TRAF_bd~MAP3K_TRAF_bd, MAP3K_TRAF_bd~Pkinase, Pkinase~Pkinase
Common GO terms GO:0000287 - magnesium ion binding
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0007254 - JNK cascade
GO:0038066 - p38MAPK cascade
and 1 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1288
Hs

1 1374
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+ Mm
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+ Rn
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+ At
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+ Hs

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Last updated: 11Aug2025