HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: E41L1 (Q9H4G0)
Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)
Gene: EPB41L1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 881
+	Hs
		204585 EGFR_HUMAN (1-1210): 0: 1241: 100.00		E41L2_HUMAN (3-875): 0: 561: 42.93
+	Hs
		339186 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TLN1_HUMAN (42-879): 3.41e-119: 401: 10.75
+	Hs
		338026 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MERL_HUMAN (87-655): 2.08e-128: 400: 22.05
+	Hs
		337871 EGFR_HUMAN (1-1210): 0: 1241: 100.00		EZRI_HUMAN (94-672): 1.1e-123: 387: 22.83
+	Hs
		338027 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RADI_HUMAN (94-672): 2.79e-119: 376: 21.44
+	Hs
		383622 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTN3_HUMAN (69-717): 3e-138: 436: 24.14
+	Hs
		384045 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TLN1_HUMAN (42-879): 3.41e-119: 401: 10.75
+	Hs
		383650 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MERL_HUMAN (87-655): 2.08e-128: 400: 22.05
+	Hs
		383579 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		EZRI_HUMAN (94-672): 1.1e-123: 387: 22.83
+	Hs
		383651 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RADI_HUMAN (94-672): 2.79e-119: 376: 21.44
+	Hs
		546927 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		EZRI_HUMAN (94-672): 1.1e-123: 387: 22.83
+	Hs
		434319 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		TLN1_HUMAN (42-879): 3.41e-119: 401: 10.75
+	Hs
		434144 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		MERL_HUMAN (87-655): 2.08e-128: 400: 22.05
+	Hs
		411302 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PTN3_HUMAN (69-717): 3e-138: 436: 24.14
+	Hs
		434145 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		RADI_HUMAN (94-672): 2.79e-119: 376: 21.44
+	Hs
		665554 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		MERL_HUMAN (87-655): 2.08e-128: 400: 22.05
+	Hs
		665337 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		E41LA_HUMAN (94-761): 3.88e-129: 405: 24.60
+	Hs
		665158 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		MERL_HUMAN (87-655): 2.08e-128: 400: 22.05
+	Hs
		546943 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		EZRI_HUMAN (94-672): 1.1e-123: 387: 22.83
+	Hs
		665555 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		RADI_HUMAN (94-672): 2.79e-119: 376: 21.44