HitPredict

Interactor 1: KLF8 (O95600)
Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741)
Gene: KLF8

Interactor 2: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35140242
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 215
+	Hs
		339832 KLF8_HUMAN (1-356): 4.04e-92: 281: 100.00		CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34
+	Hs
		339648 KLF8_HUMAN (1-356): 4.04e-92: 281: 100.00		UBF1_HUMAN (10-158): 4.17e-09: 57.8: 23.60
+	Hs
		1401471 KLF12_HUMAN (44-356): 5.86e-85: 264: 42.58		CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34
+	Mm
		991149 KLF4_MOUSE (53-356): 5.4e-49: 173: 29.19		HMGB1_MOUSE (1-174): 9.5e-45: 150: 100.00
+	Hs
		1024248 KLF12_HUMAN (44-356): 5.86e-85: 264: 42.58		TFAM_HUMAN (95-186): 2.96e-09: 57.1: 17.39
+	Mm
		313408 SP1_MOUSE (63-358): 2.54e-62: 214: 27.39		SOX8_MOUSE (7-86): 7.9e-22: 94.4: 18.75
+	Hs
		872409 ZN362_HUMAN (49-356): 1.45e-52: 181: 24.50		SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91
+	Ce
		264209 KLF2_CAEEL (268-358): 1.41e-40: 146: 70.33		SEM2_CAEEL (61-161): 2.84e-29: 114: 20.79
+	Ce
		1345569 KLF1_CAEEL (246-356): 7.54e-38: 143: 60.36		SEM2_CAEEL (61-161): 2.84e-29: 114: 20.79
+	Hs
		1211568 ZN362_HUMAN (49-356): 1.45e-52: 181: 24.50		CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34
+	Ce
		1171168 KLF1_CAEEL (246-356): 7.54e-38: 143: 60.36		EGL13_CAEEL (4-96): 4.53e-24: 100: 19.36
+	Hs
		944726 KLF3_HUMAN (22-356): 2.02e-51: 176: 33.71		CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34
+	Hs
		944628 KLF3_HUMAN (22-356): 2.02e-51: 176: 33.71		TFAM_HUMAN (95-186): 2.96e-09: 57.1: 17.39
+	Hs
		1118764 KLF5_HUMAN (267-356): 1.19e-41: 152: 78.89		CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34
+	Hs
		1401433 KLF15_HUMAN (272-356): 1.38e-31: 125: 63.53		CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34
+	Mm
		62733 A4QPD1_MOUSE (278-357): 1.24e-13: 74.4: 30.21		Q60I23_MOUSE (3-94): 1.01e-24: 100: 23.91
+	Hs
		604731 KLF16_HUMAN (274-356): 1.56e-29: 115: 61.45		UBF1_HUMAN (10-158): 4.17e-09: 57.8: 23.60
+	Hs
		1024165 KLF16_HUMAN (274-356): 1.56e-29: 115: 61.45		TFAM_HUMAN (95-186): 2.96e-09: 57.1: 17.39
+	Hs
		1153659 ZKSC8_HUMAN (71-169): 4.86e-20: 93.1: 11.00		CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34
+	Hs
		604647 ZN543_HUMAN (83-185): 1.33e-18: 88.9: 11.65		UBF1_HUMAN (10-158): 4.17e-09: 57.8: 23.60