HitPredict

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: MCP (P15529)
Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)
Gene: CD46

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.924

The method score is based on:

Property Details
Experiments 11971006, 2141838, 10960475, 8666815, 23086448
Identification Methods protease assay, pull down, solid phase assay, enzyme linked immunosorbent assay
Interaction Type protein cleavage, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains A2M~Sushi, A2M_BRD~Sushi, MG1~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0006958 - complement activation, classical pathway
GO:0009986 - cell surface
GO:0070062 - extracellular exosome
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1663
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Last updated: 15 Jul 2024