Interactor 1: SAMP (P02743)
Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]
Gene: APCS

Interactor 2: SAMP (P02743)
Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]
Gene: APCS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.900

The method score is based on:

Property Details
Experiments 8114934, 19372378, 23850452, 22396542
Identification Methods x-ray crystallography, cross-linking study, mass spectrometry studies of complexes, ion mobility mass spectrometry of complexes, comigration in non denaturing gel electrophoresis, molecular sieving
Interaction Type association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pentaxin~Pentaxin
Common GO terms GO:0001849 - complement component C1q complex binding
GO:0002674 - negative regulation of acute inflammatory response
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
and 19 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 223
Hs

1 223
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024