HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: STAT2 (P52630)
Signal transducer and activator of transcription 2 (p113)
Gene: STAT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	25402006, 24658140, unassigned2173
Identification Methods	two hybrid, protein complementation assay, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 851
+	Hs
		362914 EGFR_HUMAN (1-1210): 0: 1246: 100.00		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Hs
		362902 EGFR_HUMAN (1-1210): 0: 1246: 100.00		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		362915 EGFR_HUMAN (1-1210): 0: 1246: 100.00		STA5A_HUMAN (1-769): 0: 789: 24.67
+	Hs
		362999 EGFR_HUMAN (1-1210): 0: 1246: 100.00		STA5B_HUMAN (1-768): 0: 774: 24.67
+	Hs
		410685 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Mm
		838272 ERBB2_MOUSE (5-1203): 0: 1131: 48.34		STAT3_MOUSE (1-747): 0: 846: 37.47
+	Hs
		410680 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		838365 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		STA5A_HUMAN (1-769): 0: 789: 24.67
+	Hs
		907274 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		STA5B_HUMAN (1-768): 0: 774: 24.67
+	Hs
		463916 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Rn
		98899 INSR_RAT (579-1032): 3.03e-104: 361: 23.87		F1M9D6_RAT (1-730): 0: 882: 42.71
+	Hs
		465440 IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		907260 EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52		STA5B_HUMAN (1-768): 0: 774: 24.67
+	Hs
		838075 ACK1_HUMAN (691-967): 4.56e-56: 214: 39.58		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Hs
		838069 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Mm
		838210 ZAP70_MOUSE (718-961): 2.04e-52: 197: 40.00		STAT1_MOUSE (1-730): 0: 878: 42.51
+	Hs
		827752 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		827692 ABL2_HUMAN (707-974): 5.55e-52: 202: 40.37		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		827693 KSYK_HUMAN (716-961): 1.14e-53: 201: 41.70		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Mm
		838264 KSYK_MOUSE (718-961): 3.52e-53: 199: 42.04		STAT3_MOUSE (1-747): 0: 846: 37.47