Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.92 | 1.00 | 0.960 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24189400, 31980649, 35384245, 12471035, 23956138, unassigned2173, 25036637 |
| Identification Methods | affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, luminescence based mammalian interactome mapping |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CDC37_M~PK_Tyr_Ser-Thr, CDC37_N~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019900 - kinase binding |
| Homologous interactions | 19 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
