HitPredict

Interactor 1: IFNB (P01574)
Interferon beta (IFN-beta) (Fibroblast interferon)
Gene: IFNB1

Interactor 2: IRF1 (P10914)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	15494505, 1579446, 12077266, 11090630
Identification Methods	anti tag coimmunoprecipitation, electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0035458 - cellular response to interferon-beta GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051607 - defense response to virus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 187 Hs			1 325
+	Hs
		378227 IFNA1_HUMAN (10-186): 1.83e-74: 223: 31.49		IRF1_HUMAN (1-325): 2.67e-166: 467: 100.00
+	Hs
		378248 IFNA2_HUMAN (23-187): 2.09e-72: 218: 33.73		IRF1_HUMAN (1-325): 2.67e-166: 467: 100.00
+	Hs
		378326 IFN14_HUMAN (10-186): 1.72e-71: 216: 32.60		IRF1_HUMAN (1-325): 2.67e-166: 467: 100.00
+	Hs
		378372 IFNB_HUMAN (1-187): 1.54e-76: 228: 100.00		IRF8_HUMAN (7-270): 1.22e-99: 301: 28.79
+	Hs
		378356 IFNB_HUMAN (1-187): 1.54e-76: 228: 100.00		IRF2_HUMAN (1-268): 2.01e-86: 265: 45.55
+	Mm
		378382 IFNB_MOUSE (1-187): 4.51e-60: 186: 49.20		IRF8_MOUSE (7-270): 2.83e-94: 287: 28.03
+	Hs
		378377 IFNB_HUMAN (1-187): 1.54e-76: 228: 100.00		IRF3_HUMAN (1-263): 7.46e-62: 204: 21.29
+	Hs
		378237 IFNA1_HUMAN (10-186): 1.83e-74: 223: 31.49		IRF3_HUMAN (1-263): 7.46e-62: 204: 21.29
+	Hs
		378252 IFNA2_HUMAN (23-187): 2.09e-72: 218: 33.73		IRF3_HUMAN (1-263): 7.46e-62: 204: 21.29
+	Hs
		378271 IFNA7_HUMAN (9-186): 3.81e-72: 218: 32.62		IRF3_HUMAN (1-263): 7.46e-62: 204: 21.29
+	Hs
		378333 IFN14_HUMAN (10-186): 1.72e-71: 216: 32.60		IRF3_HUMAN (1-263): 7.46e-62: 204: 21.29
+	Hs
		378376 IFNB_HUMAN (1-187): 1.54e-76: 228: 100.00		IRF5_HUMAN (2-297): 2.68e-54: 186: 24.05
+	Hs
		378235 IFNA1_HUMAN (10-186): 1.83e-74: 223: 31.49		IRF5_HUMAN (2-297): 2.68e-54: 186: 24.05
+	Hs
		378331 IFN14_HUMAN (10-186): 1.72e-71: 216: 32.60		IRF5_HUMAN (2-297): 2.68e-54: 186: 24.05
+	Mm
		378385 IFNB_MOUSE (1-187): 4.51e-60: 186: 49.20		IRF5_MOUSE (2-260): 3.09e-58: 196: 25.36
+	Hs
		378379 IFNB_HUMAN (1-187): 1.54e-76: 228: 100.00		IRF7_HUMAN (4-252): 9.39e-41: 150: 21.09
+	Hs
		378240 IFNA1_HUMAN (10-186): 1.83e-74: 223: 31.49		IRF7_HUMAN (4-252): 9.39e-41: 150: 21.09
+	Hs
		378257 IFNA2_HUMAN (23-187): 2.09e-72: 218: 33.73		IRF7_HUMAN (4-252): 9.39e-41: 150: 21.09
+	Hs
		378274 IFNA7_HUMAN (9-186): 3.81e-72: 218: 32.62		IRF7_HUMAN (4-252): 9.39e-41: 150: 21.09
+	Hs
		378340 IFN14_HUMAN (10-186): 1.72e-71: 216: 32.60		IRF7_HUMAN (4-252): 9.39e-41: 150: 21.09