HitPredict

Interactor 1: LEU3 (P04173)
3-isopropylmalate dehydrogenase (3-IPM-DH) (IMDH) (EC 1.1.1.85) (Beta-IPM dehydrogenase)
Gene: LEU2

Interactor 2: PHO85 (P17157)
Cyclin-dependent protein kinase PHO85 (EC 2.7.11.22) (Negative regulator of the PHO system) (Serine/threonine-protein kinase PHO85)
Gene: PHO85

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.50	0.550

Property	Details
Experiments	11805837, 16319894
Identification Methods	anti tag coimmunoprecipitation, enzymatic study
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 364 Sc			1 305
+	Sc
		565482 IDH2_YEAST (2-359): 1.4e-132: 385: 27.20		PHO85_YEAST (1-305): 6.32e-140: 398: 100.00
+	Hs
		625221 IDHP_HUMAN (4-364): 1.34e-119: 355: 15.73		CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82
+	Sc
		339487 IDH2_YEAST (2-359): 1.4e-132: 385: 27.20		CDK1_YEAST (6-299): 5.63e-128: 368: 52.17
+	Hs
		414818 IDHP_HUMAN (4-364): 1.34e-119: 355: 15.73		CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00
+	Sc
		565635 LYS12_YEAST (3-359): 4.64e-109: 325: 30.73		PHO85_YEAST (1-305): 6.32e-140: 398: 100.00
+	Sc
		339682 LYS12_YEAST (3-359): 4.64e-109: 325: 30.73		CDK1_YEAST (6-299): 5.63e-128: 368: 52.17