HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: LMNB1 (P20700)
Lamin-B1
Gene: LMNB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 26524528, 29997244, 34079125, 35271311, 31839598, 39422127, 19727227, 24623722, 25948554, 29568061, 26264872, 30021884, 33961781, 32344865, 37071682, 35575683, 39358380, 26414014, 34535262, 21346760 and 6 others

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Identification Methods affinity chromatography technology, proximity labelling technology, cross-linking study, two hybrid, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, luminescence based mammalian interactome mapping, two hybrid array, pull down and 3 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Filament~Filament, LTD~LTD
Common GO terms GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005638 - lamin filament
GO:0005652 - nuclear lamina
and 9 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 664
Hs

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Service provided by Combinatics, Japan

Last updated: 11Aug2025