HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36517590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031507 - heterochromatin formation
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 746
+	Hs
		566389 K2C5_HUMAN (24-390): 2e-117: 365: 25.95		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Hs
		876477 K2C6C_HUMAN (24-407): 2.37e-116: 361: 24.03		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Hs
		385280 K2C6A_HUMAN (23-407): 4.96e-116: 360: 23.71		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Hs
		407296 K2C6B_HUMAN (24-407): 4.84e-115: 357: 23.51		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Hs
		1042000 LMNB2_HUMAN (21-581): 2.95e-51: 189: 52.59		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Hs
		634462 LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Mm
		575069 LMNB1_MOUSE (6-580): 6.57e-53: 193: 54.17		Q6AXH7_MOUSE (1-746): 0: 833: 96.41
+	Mm
		1231041 K2C73_MOUSE (23-390): 2e-48: 180: 24.39		Q6AXH7_MOUSE (1-746): 0: 833: 96.41
+	Hs
		474700 VIME_HUMAN (27-389): 3.96e-31: 129: 28.93		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Hs
		570434 GFAP_HUMAN (27-427): 1.13e-28: 121: 27.43		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Hs
		451167 NFL_HUMAN (28-433): 1.97e-26: 115: 27.07		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Mm
		628504 VIME_MOUSE (27-394): 8.73e-32: 130: 29.35		Q6AXH7_MOUSE (1-746): 0: 833: 96.41
+	Hs
		227228 KRT86_HUMAN (250-556): 8.41e-10: 63.7: 13.25		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Hs
		355390 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		NSD2_HUMAN (275-729): 1.3e-91: 314: 16.03
+	Hs
		386110 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		NSD1_HUMAN (275-729): 2.84e-90: 312: 15.82
+	Hs
		386194 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		NSD3_HUMAN (275-729): 8.3e-70: 251: 14.42
+	Hs
		634614 LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45		NSD3_HUMAN (275-729): 8.3e-70: 251: 14.42