HitPredict

Interactor 1: HMEN (P02836)
Segmentation polarity homeobox protein engrailed
Gene: en

Interactor 2: GROU (P16371)
Protein groucho (Enhancer of split m9/10 protein) (E(spl)m9/10)
Gene: gro

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.744

Property	Details
Experiments	11311161, 16762837, 9367988, 9566899, 25242320, 18803772, unassigned4
Identification Methods	affinity chromatography technology, two hybrid, experimental interaction detection
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 552 Dm			1 730
+	Dm
		431428 HMIN_DROME (409-538): 3.33e-48: 178: 64.05		GROU_DROME (1-730): 7.6e-174: 517: 100.00
+	Dm
		594695 Q7KUL4_DROME (316-546): 7.59e-34: 132: 28.57		GROU_DROME (1-730): 7.6e-174: 517: 100.00
+	Hs
		1048182 VSX1_HUMAN (309-530): 5.94e-35: 136: 18.02		TLE4_HUMAN (1-730): 1.65e-154: 469: 60.36
+	Hs
		1047876 VSX1_HUMAN (309-530): 5.94e-35: 136: 18.02		TLE1_HUMAN (1-730): 2.45e-154: 468: 59.95
+	Hs
		1048149 HME1_HUMAN (279-542): 1.82e-31: 127: 37.27		TLE4_HUMAN (1-730): 1.65e-154: 469: 60.36
+	Hs
		885223 HXA1_HUMAN (227-527): 2.58e-32: 128: 17.94		TLE1_HUMAN (1-730): 2.45e-154: 468: 59.95
+	Hs
		1047799 HME1_HUMAN (279-542): 1.82e-31: 127: 37.27		TLE1_HUMAN (1-730): 2.45e-154: 468: 59.95
+	Hs
		624539 HME2_HUMAN (332-542): 1.62e-31: 126: 45.02		TLE1_HUMAN (1-730): 2.45e-154: 468: 59.95
+	Hs
		1048115 VSX1_HUMAN (309-530): 5.94e-35: 136: 18.02		TLE3_HUMAN (1-730): 1.79e-144: 443: 56.89
+	Hs
		1047953 HME1_HUMAN (279-542): 1.82e-31: 127: 37.27		TLE3_HUMAN (1-730): 1.79e-144: 443: 56.89
+	Hs
		1047893 HME1_HUMAN (279-542): 1.82e-31: 127: 37.27		TLE2_HUMAN (1-730): 3.36e-141: 433: 55.61
+	Ce
		146026 HM16_CAEEL (385-534): 1.82e-33: 127: 47.10		UNC37_CAEEL (20-730): 1.97e-101: 325: 36.30
+	Hs
		478676 HXB5_HUMAN (332-519): 9e-37: 139: 29.02		TLE5_HUMAN (1-197): 4.9e-83: 263: 49.51
+	Hs
		1061905 VSX1_HUMAN (309-530): 5.94e-35: 136: 18.02		TLE5_HUMAN (1-197): 4.9e-83: 263: 49.51
+	Hs
		885227 HXA1_HUMAN (227-527): 2.58e-32: 128: 17.94		TLE5_HUMAN (1-197): 4.9e-83: 263: 49.51
+	Hs
		1052861 HME1_HUMAN (279-542): 1.82e-31: 127: 37.27		TLE5_HUMAN (1-197): 4.9e-83: 263: 49.51
+	Hs
		478728 HXB5_HUMAN (332-519): 9e-37: 139: 29.02		GBB4_HUMAN (471-729): 8.45e-61: 209: 16.79
+	Mm
		965395 KMT2C_MOUSE (19-460): 1.36e-34: 142: 13.60		WDR5_MOUSE (316-470): 1.17e-13: 74.9: 7.98
+	Hs
		965022 Q6FHY5_HUMAN (280-525): 6.67e-32: 127: 19.14		WDR5_HUMAN (316-470): 1.17e-13: 74.9: 7.98
+	Hs
		893801 MEOX2_HUMAN (280-525): 9.35e-32: 126: 19.07		WDR5_HUMAN (316-470): 1.17e-13: 74.9: 7.98