HitPredict

Interactor 1: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Interactor 2: HME1 (Q05925)
Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1)
Gene: EN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	33961781, 19956621, 35140242, 16571670, 18611861
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 392
+	Hs
		885223 TLE1_HUMAN (1-770): 0: 600: 100.00		HXA1_HUMAN (140-376): 6.88e-33: 127: 22.67
+	Hs
		1047849 TLE1_HUMAN (1-770): 0: 600: 100.00		LHX4_HUMAN (296-391): 2.35e-28: 116: 28.13
+	Hs
		1048149 TLE4_HUMAN (1-770): 0: 571: 86.53		HME1_HUMAN (1-392): 7e-39: 145: 100.00
+	Hs
		942429 TLE1_HUMAN (1-770): 0: 600: 100.00		GSC_HUMAN (159-391): 1.85e-29: 116: 19.41
+	Hs
		624539 TLE1_HUMAN (1-770): 0: 600: 100.00		HME2_HUMAN (38-392): 1.76e-28: 115: 42.54
+	Hs
		1047880 TLE1_HUMAN (1-770): 0: 600: 100.00		HESX1_HUMAN (228-376): 2.95e-28: 111: 25.50
+	Hs
		942431 TLE4_HUMAN (1-770): 0: 571: 86.53		GSC_HUMAN (159-391): 1.85e-29: 116: 19.41
+	Hs
		1047953 TLE3_HUMAN (1-770): 1.2e-180: 537: 77.29		HME1_HUMAN (1-392): 7e-39: 145: 100.00
+	Hs
		942430 TLE3_HUMAN (1-770): 1.2e-180: 537: 77.29		GSC_HUMAN (159-391): 1.85e-29: 116: 19.41
+	Hs
		1047893 TLE2_HUMAN (1-770): 5.33e-153: 465: 64.33		HME1_HUMAN (1-392): 7e-39: 145: 100.00
+	Dm
		431428 GROU_DROME (1-770): 3.06e-141: 434: 59.28		HMIN_DROME (265-386): 3.59e-45: 165: 60.27
+	Dm
		594705 GROU_DROME (1-770): 3.06e-141: 434: 59.28		Q9NHP8_DROME (3-391): 2.29e-45: 165: 17.18
+	Hs
		1047892 TLE2_HUMAN (1-770): 5.33e-153: 465: 64.33		EMX2_HUMAN (156-391): 5.93e-32: 123: 24.79
+	Dm
		393684 GROU_DROME (1-770): 3.06e-141: 434: 59.28		HMEN_DROME (221-391): 7.36e-32: 128: 50.58
+	Dm
		594671 GROU_DROME (1-770): 3.06e-141: 434: 59.28		VND_DROME (3-380): 2.52e-31: 127: 16.92
+	Dm
		594680 GROU_DROME (1-770): 3.06e-141: 434: 59.28		UBX_DROME (180-361): 1.54e-30: 122: 20.67
+	Dm
		594710 GROU_DROME (1-770): 3.06e-141: 434: 59.28		Q9VDA2_DROME (54-364): 2.35e-29: 119: 16.29
+	Dm
		594679 GROU_DROME (1-770): 3.06e-141: 434: 59.28		GSC_DROME (17-371): 1.44e-28: 117: 15.49
+	Hs
		885227 TLE5_HUMAN (1-200): 4.92e-91: 285: 64.50		HXA1_HUMAN (140-376): 6.88e-33: 127: 22.67
+	Hs
		478676 TLE5_HUMAN (1-200): 4.92e-91: 285: 64.50		HXB5_HUMAN (196-366): 1.41e-31: 122: 28.07