HitPredict

Interactor 1: CCNE1 (P24864)
G1/S-specific cyclin-E1
Gene: CCNE1

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 15980415, 21241890, 25728284, 28137908, 29439025, 12839982, 24771265, 9891079, 1388288, 15004009, 12529437, 19858290, 20837141, 16223725, 21372285, 17970072, 17431037, 17361108, 15514162, 14701826 and 38 others

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Identification Methods pull down, affinity chromatography technology, biochemical, enzymatic study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, tandem affinity purification
Interaction Type direct interaction, physical association, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 5 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 410
Hs

1 298
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024