HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: CD3Z (P20963)
T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)
Gene: CD247

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 0.60 0.711

The method score is based on:

Property Details
Experiments 26390156, 14523017, 24463463, 16461343, 8626561
Identification Methods affinity chromatography technology, protein kinase assay, pull down
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0038094 - Fc-gamma receptor signaling pathway
GO:0050852 - T cell receptor signaling pathway
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 509
Hs

1 164
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024