HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	11551902
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 481
+	Mm
		581958 INSR_MOUSE (1-1382): 0: 1494: 94.22		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		581969 INSR_MOUSE (1-1382): 0: 1494: 94.22		DOK3_MOUSE (1-458): 4.83e-120: 360: 30.90
+	Rn
		580450 INSR_RAT (1-1382): 0: 1513: 94.29		IRS1_RAT (6-373): 3.7e-78: 267: 17.27
+	Hs
		439666 INSR_HUMAN (1-1382): 0: 1513: 100.00		IRS1_HUMAN (6-373): 1.96e-76: 262: 16.33
+	Mm
		581954 INSR_MOUSE (1-1382): 0: 1494: 94.22		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Hs
		439887 INSR_HUMAN (1-1382): 0: 1513: 100.00		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Hs
		439799 INSR_HUMAN (1-1382): 0: 1513: 100.00		FRS2_HUMAN (154-464): 2.54e-54: 191: 21.09
+	Mm
		772558 IGF1R_MOUSE (19-1380): 0: 1343: 55.37		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Hs
		465432 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		IRS1_HUMAN (6-373): 1.96e-76: 262: 16.33
+	Hs
		465699 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Dm
		479740 INSR_DROME (30-1382): 0: 999: 34.31		IRS1_DROME (26-343): 3.56e-69: 239: 15.03
+	Hs
		160421 EPHA2_HUMAN (521-1320): 1.66e-176: 552: 20.02		IRS4_HUMAN (6-404): 5.58e-95: 314: 14.35
+	Mm
		772552 EPHA2_MOUSE (521-1320): 2.17e-171: 539: 20.48		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Hs
		932105 EPHA4_HUMAN (521-1352): 0: 576: 21.14		FRS2_HUMAN (154-464): 2.54e-54: 191: 21.09
+	Hs
		710393 EPHA2_HUMAN (521-1320): 1.66e-176: 552: 20.02		FRS2_HUMAN (154-464): 2.54e-54: 191: 21.09
+	Hs
		160643 ALK_HUMAN (982-1339): 1.97e-70: 263: 40.53		IRS4_HUMAN (6-404): 5.58e-95: 314: 14.35
+	Hs
		772530 ALK_HUMAN (982-1339): 1.97e-70: 263: 40.53		IRS1_HUMAN (6-373): 1.96e-76: 262: 16.33
+	Hs
		1462015 ALK_HUMAN (982-1339): 1.97e-70: 263: 40.53		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Hs
		1356248 ALK_HUMAN (982-1339): 1.97e-70: 263: 40.53		FRS2_HUMAN (154-464): 2.54e-54: 191: 21.09
+	Hs
		711919 LTK_HUMAN (1013-1291): 2.01e-71: 259: 44.52		FRS2_HUMAN (154-464): 2.54e-54: 191: 21.09