HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: MED28 (Q9H204)
Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)
Gene: MED28

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.649

Property	Details
Experiments	16964398, 16899217
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, protein kinase assay, pull down, peptide array
Interaction Type	physical association, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 178
+	Mm
		763402 FYN_MOUSE (1-537): 0: 642: 99.44		MED28_MOUSE (1-178): 8.45e-99: 284: 94.38
+	Hs
		523146 SRC_HUMAN (1-537): 0: 598: 68.21		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		433471 YES_HUMAN (1-537): 0: 591: 71.61		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		411851 LCK_HUMAN (40-535): 0: 551: 57.60		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		442883 HCK_HUMAN (1-535): 0: 548: 56.64		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		789091 ABL2_HUMAN (7-537): 2.06e-170: 515: 38.09		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		789008 TEC_HUMAN (5-529): 6.12e-163: 478: 34.89		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		986396 BTK_HUMAN (5-531): 1.1e-153: 456: 31.02		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00