HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: H2B1H (Q93079)
Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)
Gene: H2BC9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BAH~Histone
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1616 Hs			1 126
+	Hs
		641157 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83
+	Hs
		641186 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Xl
		355250 P79922_XENLA (126-1616): 0: 1502: 70.07		H2B11_XENLA (1-126): 7.7e-54: 166: 92.86
+	Hs
		1087228 PB1_HUMAN (42-1162): 0: 602: 15.37		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		707673 PB1_HUMAN (42-1162): 0: 602: 15.37		H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83
+	Hs
		918481 PB1_HUMAN (42-1162): 0: 602: 15.37		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Nc
		740443 Q3Y3Z1_NEUCR (1040-1604): 1.28e-120: 416: 22.53		H2B_NEUCR (2-125): 1.61e-36: 123: 70.97
+	Hs
		1274480 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		H2B1H_HUMAN (1-126): 4.31e-55: 169: 100.00
+	Hs
		420896 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		H2B1J_HUMAN (1-126): 7.3e-55: 169: 97.62
+	Hs
		241662 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		918774 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Hs
		918802 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Hs
		918628 MINT_HUMAN (5-706): 1.98e-35: 150: 12.71		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	At
		188588 DRM2_ARATH (1090-1262): 3.7e-36: 149: 17.68		H2B6_ARATH (4-125): 9.04e-41: 134: 65.87
+	Hs
		1087196 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		918442 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21