HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: PHAG1 (Q9NWQ8)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)
Gene: PAG1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	10790433, 18056706, 23866081
Identification Methods	pull down, affinity chromatography technology, coimmunoprecipitation, peptide array, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PAG~SH2
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0045121 - membrane raft
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 432
+	Mm
		763390 FYN_MOUSE (1-537): 0: 642: 99.44		PHAG1_MOUSE (1-432): 0: 759: 78.21
+	Hs
		523175 SRC_HUMAN (1-537): 0: 598: 68.21		PHAG1_HUMAN (1-432): 0: 755: 100.00
+	Mm
		411925 LCK_MOUSE (40-535): 0: 553: 57.20		PHAG1_MOUSE (1-432): 0: 759: 78.21
+	Hs
		411873 LCK_HUMAN (40-535): 0: 551: 57.60		PHAG1_HUMAN (1-432): 0: 755: 100.00
+	Mm
		639443 LYN_MOUSE (1-535): 0: 535: 53.92		PHAG1_MOUSE (1-432): 0: 759: 78.21
+	Hs
		434038 LYN_HUMAN (1-535): 0: 535: 54.48		PHAG1_HUMAN (1-432): 0: 755: 100.00
+	Hs
		789135 FRK_HUMAN (77-529): 6.35e-176: 507: 52.26		PHAG1_HUMAN (1-432): 0: 755: 100.00
+	Hs
		337571 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		PHAG1_HUMAN (1-432): 0: 755: 100.00
+	Rn
		693647 CSK_RAT (73-525): 6.21e-174: 500: 36.44		PHAG1_RAT (1-432): 0: 740: 79.13
+	Mm
		976830 ITK_MOUSE (5-526): 6.73e-164: 480: 32.77		PHAG1_MOUSE (1-432): 0: 759: 78.21