HitPredict

Interactor 1: KIT (P05532)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
Gene: KIT

Interactor 2: SH2B1 (Q91ZM2)
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)
Gene: SH2B1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	10679268
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0030032 - lamellipodium assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 979 Mm			1 756
+	Hs
		532087 KIT_HUMAN (1-978): 0: 803: 79.96		TENS3_HUMAN (7-744): 1.34e-83: 292: 11.87
+	Hs
		532086 KIT_HUMAN (1-978): 0: 803: 79.96		TENS2_HUMAN (77-743): 2.45e-81: 285: 12.59
+	Hs
		532060 KIT_HUMAN (1-978): 0: 803: 79.96		KSYK_HUMAN (349-716): 5.58e-59: 213: 14.70
+	Hs
		532056 KIT_HUMAN (1-978): 0: 803: 79.96		TEC_HUMAN (291-644): 1.55e-58: 211: 14.80
+	Mm
		431455 KIT_MOUSE (1-979): 0: 833: 96.85		MATK_MOUSE (432-636): 2.63e-47: 177: 19.91
+	Hs
		532051 KIT_HUMAN (1-978): 0: 803: 79.96		SHC1_HUMAN (89-625): 3.89e-56: 204: 19.06
+	Hs
		532088 KIT_HUMAN (1-978): 0: 803: 79.96		SHC4_HUMAN (328-631): 5.74e-55: 201: 19.81
+	Hs
		440316 KIT_HUMAN (1-978): 0: 803: 79.96		FYN_HUMAN (374-643): 2.89e-52: 192: 13.00
+	Hs
		439920 KIT_HUMAN (1-978): 0: 803: 79.96		LCK_HUMAN (395-700): 9.1e-52: 190: 15.66
+	Hs
		532036 KIT_HUMAN (1-978): 0: 803: 79.96		SRC_HUMAN (394-645): 3.33e-51: 189: 13.43
+	Hs
		462957 KIT_HUMAN (1-978): 0: 803: 79.96		YES_HUMAN (388-645): 1.13e-50: 188: 14.18
+	Hs
		473354 KIT_HUMAN (1-978): 0: 803: 79.96		HCK_HUMAN (372-701): 1.69e-50: 187: 13.99
+	Hs
		532070 KIT_HUMAN (1-978): 0: 803: 79.96		SHC2_HUMAN (328-628): 4.4e-46: 175: 21.10
+	Mm
		148471 KIT_MOUSE (1-979): 0: 833: 96.85		P85B_MOUSE (335-651): 1.36e-34: 142: 15.00
+	Hs
		532057 KIT_HUMAN (1-978): 0: 803: 79.96		TXK_HUMAN (411-625): 6.56e-45: 171: 16.30
+	Hs
		532055 KIT_HUMAN (1-978): 0: 803: 79.96		MATK_HUMAN (432-641): 2.56e-43: 166: 19.44
+	Hs
		136269 KIT_HUMAN (1-978): 0: 803: 79.96		P85B_HUMAN (307-651): 8.64e-35: 143: 15.78
+	Hs
		532094 KIT_HUMAN (1-978): 0: 803: 79.96		SHC3_HUMAN (403-616): 4.51e-26: 115: 19.62
+	Mm
		431458 KIT_MOUSE (1-979): 0: 833: 96.85		GRB2_MOUSE (517-609): 7.68e-15: 76.2: 22.58
+	Hs
		532067 KIT_HUMAN (1-978): 0: 803: 79.96		GRB2_HUMAN (517-609): 7.68e-15: 76.2: 22.58