HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: RIN1 (Q13671)
Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)
Gene: RIN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12783862
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 783
+	Rn
		98571 INSR_RAT (1-1382): 0: 1513: 94.29		F1LN91_RAT (26-227): 1.02e-41: 167: 19.27
+	Hs
		193174 INSR_HUMAN (1-1382): 0: 1513: 100.00		SOCS1_HUMAN (49-192): 4.76e-26: 108: 24.32
+	Mm
		205419 INSR_MOUSE (1-1382): 0: 1494: 94.22		SOCS1_MOUSE (49-192): 2.49e-26: 109: 24.32
+	Hs
		193183 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		SOCS1_HUMAN (49-192): 4.76e-26: 108: 24.32
+	Mm
		1041409 EPHA4_MOUSE (521-1359): 0: 578: 20.97		RIN1_MOUSE (1-783): 0: 669: 77.23
+	Hs
		640163 EPHA1_HUMAN (675-1320): 4.9e-157: 501: 22.78		RIN1_HUMAN (1-783): 0: 717: 100.00
+	Hs
		641595 ERBB3_HUMAN (33-369): 2.6e-27: 123: 20.11		RIN1_HUMAN (1-783): 0: 717: 100.00
+	Hs
		410827 ERBB2_HUMAN (32-343): 3.5e-21: 102: 20.74		RIN1_HUMAN (1-783): 0: 717: 100.00
+	Hs
		932087 EPHA4_HUMAN (521-1352): 0: 576: 21.14		TENS3_HUMAN (28-227): 1.04e-41: 167: 20.37
+	Hs
		932134 EPHA4_HUMAN (521-1352): 0: 576: 21.14		SLAP2_HUMAN (69-170): 1.52e-24: 105: 24.76
+	Hs
		411948 NTRK1_HUMAN (996-1286): 9.2e-68: 247: 42.62		GAPD1_HUMAN (132-593): 1.28e-103: 350: 13.18
+	Hs
		412772 NTRK1_HUMAN (996-1286): 9.2e-68: 247: 42.62		RABX5_HUMAN (287-630): 4.47e-96: 309: 14.29
+	Hs
		193311 ALK_HUMAN (982-1339): 1.97e-70: 263: 40.53		SOCS1_HUMAN (49-192): 4.76e-26: 108: 24.32
+	Hs
		193207 FGFR3_HUMAN (1015-1287): 2.22e-62: 231: 40.78		SOCS1_HUMAN (49-192): 4.76e-26: 108: 24.32
+	Hs
		641612 ERBB3_HUMAN (33-369): 2.6e-27: 123: 20.11		TENS3_HUMAN (28-227): 1.04e-41: 167: 20.37
+	Hs
		641611 ERBB3_HUMAN (33-369): 2.6e-27: 123: 20.11		TENS2_HUMAN (4-230): 5.07e-37: 152: 18.60
+	Hs
		641679 ERBB3_HUMAN (33-369): 2.6e-27: 123: 20.11		TENS1_HUMAN (10-225): 2.63e-35: 147: 16.46
+	Hs
		641622 ERBB3_HUMAN (33-369): 2.6e-27: 123: 20.11		TENS4_HUMAN (2-214): 3.95e-33: 138: 17.67
+	Hs
		641675 ERBB3_HUMAN (33-369): 2.6e-27: 123: 20.11		SLAP2_HUMAN (69-170): 1.52e-24: 105: 24.76
+	Hs
		193169 ERBB2_HUMAN (32-343): 3.5e-21: 102: 20.74		SOCS1_HUMAN (49-192): 4.76e-26: 108: 24.32