HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: CKS2 (P33552)
Cyclin-dependent kinases regulatory subunit 2 (CKS-2)
Gene: CKS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.981

Property	Details
Experiments	25852190, 26186194, 26496610, 1944283, 32707033, 36736316, 35235311, 18471975, 23602568, 28514442, 33961781, 19786724
Identification Methods	affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0003682 - chromatin binding GO:0048144 - fibroblast proliferation GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Hs			1 79
+	Hs
		667697 CDK2_HUMAN (1-297): 4.63e-149: 421: 65.32		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		667577 CDK2_HUMAN (1-297): 4.63e-149: 421: 65.32		CKS2_HUMAN (1-79): 8.62e-38: 122: 100.00
+	Hs
		956646 CDK3_HUMAN (1-289): 4.73e-144: 408: 66.78		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		443287 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		753913 CDK3_HUMAN (1-289): 4.73e-144: 408: 66.78		CKS2_HUMAN (1-79): 8.62e-38: 122: 100.00
+	At
		663937 CDKA1_ARATH (1-290): 2.67e-137: 391: 67.01		CKS2_ARATH (5-78): 2.5e-39: 126: 66.22
+	At
		200085 CDKA1_ARATH (1-290): 2.67e-137: 391: 67.01		CKS1_ARATH (5-73): 5.94e-38: 123: 68.12
+	Dm
		660412 CDK1_DROME (1-290): 6.42e-136: 388: 73.45		Q9VHN1_DROME (1-71): 3.96e-38: 123: 69.01
+	Hs
		956647 CDK5_HUMAN (1-293): 8.35e-134: 382: 56.12		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	At
		1423230 CDKD1_ARATH (2-297): 1.45e-130: 378: 47.30		CKS2_ARATH (5-78): 2.5e-39: 126: 66.22
+	Dm
		660384 CDK1_DROME (1-290): 6.42e-136: 388: 73.45		CKS1_DROME (3-72): 1.5e-35: 116: 77.14
+	At
		683028 CKB11_ARATH (1-292): 8.91e-132: 378: 52.12		CKS2_ARATH (5-78): 2.5e-39: 126: 66.22
+	Hs
		753914 CDK5_HUMAN (1-293): 8.35e-134: 382: 56.12		CKS2_HUMAN (1-79): 8.62e-38: 122: 100.00
+	At
		1320106 CKB21_ARATH (1-295): 7.17e-131: 375: 53.14		CKS2_ARATH (5-78): 2.5e-39: 126: 66.22
+	At
		200086 CKB11_ARATH (1-292): 8.91e-132: 378: 52.12		CKS1_ARATH (5-73): 5.94e-38: 123: 68.12
+	At
		1320238 CKB22_ARATH (1-295): 3.18e-130: 374: 57.10		CKS2_ARATH (5-78): 2.5e-39: 126: 66.22
+	At
		200105 CKB21_ARATH (1-295): 7.17e-131: 375: 53.14		CKS1_ARATH (5-73): 5.94e-38: 123: 68.12
+	At
		200106 CKB22_ARATH (1-295): 3.18e-130: 374: 57.10		CKS1_ARATH (5-73): 5.94e-38: 123: 68.12
+	At
		200112 CDKD2_ARATH (1-296): 1.36e-129: 373: 45.61		CKS1_ARATH (5-73): 5.94e-38: 123: 68.12
+	Sp
		410432 CDK1_SCHPO (1-291): 8.08e-132: 377: 63.64		CKS1_SCHPO (4-78): 2.52e-31: 107: 47.62