HitPredict

Interactor 1: CKS1 (P61024)
Cyclin-dependent kinases regulatory subunit 1 (CKS-1)
Gene: CKS1B

Interactor 2: CDK3 (Q00526)
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
Gene: CDK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	28514442, 32296183, 33961781, 26186194, 23602568, 7809159, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, validated two hybrid, two hybrid array, two hybrid prey pooling approach, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 79 Hs			1 305
+	Hs
		753913 CKS2_HUMAN (1-79): 5.7e-38: 122: 81.01		CDK3_HUMAN (1-305): 1.94e-152: 430: 100.00
+	Hs
		667697 CKS1_HUMAN (1-79): 9.4e-40: 127: 100.00		CDK2_HUMAN (1-292): 2.7e-149: 422: 76.71
+	Hs
		667577 CKS2_HUMAN (1-79): 5.7e-38: 122: 81.01		CDK2_HUMAN (1-292): 2.7e-149: 422: 76.71
+	Hs
		443287 CKS1_HUMAN (1-79): 9.4e-40: 127: 100.00		CDK1_HUMAN (1-290): 2.25e-138: 394: 65.98
+	At
		200085 CKS1_ARATH (5-73): 1.36e-37: 122: 69.57		CDKA1_ARATH (1-293): 1.94e-138: 394: 68.03
+	Hs
		443221 CKS2_HUMAN (1-79): 5.7e-38: 122: 81.01		CDK1_HUMAN (1-290): 2.25e-138: 394: 65.98
+	At
		663937 CKS2_ARATH (5-78): 3.47e-37: 120: 67.57		CDKA1_ARATH (1-293): 1.94e-138: 394: 68.03
+	Hs
		956647 CKS1_HUMAN (1-79): 9.4e-40: 127: 100.00		CDK5_HUMAN (1-292): 2.37e-133: 381: 60.75
+	Ce
		759628 CKS1_CAEEL (4-78): 6.96e-42: 133: 65.33		CDK1_CAEEL (1-294): 6.51e-130: 374: 62.25
+	Dm
		660412 Q9VHN1_DROME (1-71): 6.8e-38: 123: 71.83		CDK1_DROME (1-287): 3.06e-134: 383: 65.63
+	Hs
		753914 CKS2_HUMAN (1-79): 5.7e-38: 122: 81.01		CDK5_HUMAN (1-292): 2.37e-133: 381: 60.75
+	At
		200096 CKS1_ARATH (5-73): 1.36e-37: 122: 69.57		CKB12_ARATH (1-292): 2.42e-131: 377: 56.77
+	At
		1180621 CKS2_ARATH (5-78): 3.47e-37: 120: 67.57		CKB12_ARATH (1-292): 2.42e-131: 377: 56.77
+	Dm
		660468 Q9VHN1_DROME (1-71): 6.8e-38: 123: 71.83		CDK2_DROME (1-301): 9.42e-130: 373: 60.47
+	At
		200105 CKS1_ARATH (5-73): 1.36e-37: 122: 69.57		CKB21_ARATH (1-295): 1.09e-129: 373: 50.99
+	At
		200106 CKS1_ARATH (5-73): 1.36e-37: 122: 69.57		CKB22_ARATH (1-295): 2.4e-129: 372: 51.65
+	At
		1320106 CKS2_ARATH (5-78): 3.47e-37: 120: 67.57		CKB21_ARATH (1-295): 1.09e-129: 373: 50.99
+	At
		200112 CKS1_ARATH (5-73): 1.36e-37: 122: 69.57		CDKD2_ARATH (1-302): 1.29e-128: 371: 48.01
+	At
		200086 CKS1_ARATH (5-73): 1.36e-37: 122: 69.57		CKB11_ARATH (1-292): 5.78e-126: 363: 56.17
+	At
		683028 CKS2_ARATH (5-78): 3.47e-37: 120: 67.57		CKB11_ARATH (1-292): 5.78e-126: 363: 56.17