HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: CKS2 (P33552)
Cyclin-dependent kinases regulatory subunit 2 (CKS-2)
Gene: CKS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	28514442, 33961781, 19786724, 25852190, 26186194, 26496610, 23455922, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0007346 - regulation of mitotic cell cycle GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Hs			1 79
+	Hs
		667697 CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		956646 CDK3_HUMAN (1-294): 4.77e-154: 434: 76.87		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		753913 CDK3_HUMAN (1-294): 4.77e-154: 434: 76.87		CKS2_HUMAN (1-79): 8.62e-38: 122: 100.00
+	Hs
		443287 CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	At
		663937 CDKA1_ARATH (1-289): 3.08e-144: 408: 68.62		CKS2_ARATH (5-78): 2.5e-39: 126: 66.22
+	At
		200085 CDKA1_ARATH (1-289): 3.08e-144: 408: 68.62		CKS1_ARATH (5-73): 5.94e-38: 123: 68.12
+	Hs
		443221 CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90		CKS2_HUMAN (1-79): 8.62e-38: 122: 100.00
+	Hs
		956647 CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Dm
		660412 CDK1_DROME (1-289): 3.7e-139: 396: 63.45		Q9VHN1_DROME (1-71): 3.96e-38: 123: 69.01
+	Hs
		753914 CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39		CKS2_HUMAN (1-79): 8.62e-38: 122: 100.00
+	At
		1423230 CDKD1_ARATH (2-298): 6.08e-134: 386: 47.48		CKS2_ARATH (5-78): 2.5e-39: 126: 66.22
+	Dm
		660384 CDK1_DROME (1-289): 3.7e-139: 396: 63.45		CKS1_DROME (3-72): 1.5e-35: 116: 77.14
+	At
		1180621 CKB12_ARATH (1-291): 1.58e-132: 380: 56.31		CKS2_ARATH (5-78): 2.5e-39: 126: 66.22
+	At
		1423183 CDKD2_ARATH (1-298): 6.25e-132: 379: 46.31		CKS2_ARATH (5-78): 2.5e-39: 126: 66.22
+	Dm
		660468 CDK2_DROME (1-289): 1.6e-133: 382: 63.67		Q9VHN1_DROME (1-71): 3.96e-38: 123: 69.01
+	At
		200096 CKB12_ARATH (1-291): 1.58e-132: 380: 56.31		CKS1_ARATH (5-73): 5.94e-38: 123: 68.12
+	At
		200112 CDKD2_ARATH (1-298): 6.25e-132: 379: 46.31		CKS1_ARATH (5-73): 5.94e-38: 123: 68.12
+	Dm
		660434 CDK2_DROME (1-289): 1.6e-133: 382: 63.67		CKS1_DROME (3-72): 1.5e-35: 116: 77.14
+	Sp
		410432 CDK1_SCHPO (1-290): 1.05e-136: 390: 65.32		CKS1_SCHPO (4-78): 2.52e-31: 107: 47.62
+	Sc
		364323 CDK1_YEAST (1-288): 6.05e-132: 378: 62.12		CKS1_YEAST (4-78): 2.02e-33: 113: 48.81