Interactor 1: NFL (P07196)
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)
Gene: NEFL
Interactor 2: DESM (P17661)
Desmin
Gene: DES
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.89 | 1.00 | 0.946 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26871637, 32296183, 33961781, 34349018, unassigned1304, 27107012 |
| Identification Methods | two hybrid, affinity chromatography technology, cross-linking study, two hybrid array, validated two hybrid, split luciferase complementation, two hybrid prey pooling approach, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Filament~Filament |
| Common GO terms | GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0031594 - neuromuscular junction GO:0045109 - intermediate filament organization |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
