HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29117863
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 630
+	Hs
		1052747 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		TRI25_HUMAN (1-630): 3.52e-149: 447: 100.00
+	Hs
		1048059 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		TRI25_HUMAN (1-630): 3.52e-149: 447: 100.00
+	Hs
		1031326 PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56		TRI25_HUMAN (1-630): 3.52e-149: 447: 100.00
+	Hs
		201669 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		TRI14_HUMAN (155-624): 1.74e-75: 249: 18.45
+	Hs
		453431 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		201684 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1171194 DAZP1_HUMAN (8-365): 1.46e-57: 194: 24.87		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1104155 RA1L2_HUMAN (1-302): 4.03e-58: 193: 83.44		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		162076 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		609923 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		852088 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		609858 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		TRI29_HUMAN (84-348): 1.63e-61: 216: 28.67
+	Hs
		1171683 PABP3_HUMAN (6-193): 6.86e-35: 137: 17.90		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1171402 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1020280 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1048056 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		TRI14_HUMAN (155-624): 1.74e-75: 249: 18.45
+	Hs
		1048115 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1171177 MSI2H_HUMAN (2-91): 6.69e-16: 79.8: 35.56		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		610111 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		TRI35_HUMAN (9-80): 1.95e-10: 65.5: 45.21
+	Hs
		111141 I6L957_HUMAN (105-192): 1.18e-21: 94.5: 34.09		TRI35_HUMAN (9-80): 1.95e-10: 65.5: 45.21