Protein: PYR1
Multifunctional protein r (Protein rudimentary) [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]

Gene: PYR1, r
Organism: Drosophila melanogaster
Interactions: 60
UniProt ID: P05990

Gene Ontology (top 5):
GO:0004070 - aspartate carbamoyltransferase activity
GO:0004087 - carbamoyl-phosphate synthase (ammonia) activity
GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151 - dihydroorotase activity
GO:0004359 - glutaminase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

437989

Q7KN97
Pyruvate carboxylase

1

6

High-throughput

0.618

High

437983

Q0E9E2
Pyruvate carboxylase

1

5

High-throughput

0.575

High

437999

Q9V470
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

2

1

High-throughput

0.571

High

438003

Q9VAW3
glutamine--fructose-6-phosphate transaminase

2

1

High-throughput

0.571

High

438008

NFS1
Cysteine desulfurase, mitochondrial

2

1

High-throughput

0.571

High

438011

Q9VQL1
serine--tRNA ligase

2

1

High-throughput

0.571

High

437973

SYEP
Bifunctional glutamate/proline--tRNA ligase

2

0

High-throughput

0.547

High

437976

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

2

0

High-throughput

0.547

High

437988

Q7K3H0
LD28067p

2

0

High-throughput

0.547

High

55405

A1Z9E3
Elongation factor Tu

2

1

High-throughput

0.521

High

438018

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

2

3

High-throughput

0.521

High

437984

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.508

High

58300

A1ZBJ8
FI19908p1

1

0

High-throughput

0.486

High

438014

Q9VSE6
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.481

High

437978

TCPG
T-complex protein 1 subunit gamma

1

3

High-throughput

0.479

High

438005

CARM1
Probable histone-arginine methyltransferase CARMER

1

2

High-throughput

0.479

High

438012

Q9VR42
Serine/threonine-protein kinase RIO3

1

3

High-throughput

0.479

High

438020

Q9VYT3
FI23714p1

1

2

Small-scale

0.479

High

438022

Q9Y162
vesicle-fusing ATPase

1

9

High-throughput

0.479

High

437991

MESD
LDLR chaperone boca

1

0

High-throughput

0.458

High

438013

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

437995

Q9NH11
DNA 3'-5' helicase

1

3

High-throughput

0.457

High

118752

M9NFI9
Neurabin-1

1

5

High-throughput

0.445

High

263551

O61444
mitogen-activated protein kinase kinase

1

10

High-throughput

0.445

High

437979

HYD
E3 ubiquitin-protein ligase hyd

1

11

High-throughput

0.445

High

437980

PFKA
ATP-dependent 6-phosphofructokinase

1

1

High-throughput

0.445

High

437986

MCM4
DNA replication licensing factor MCM4

1

6

High-throughput

0.445

High

437990

Q8MSW0
Isoleucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.445

High

437992

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

1

High-throughput

0.445

High

437996

Q9V405
26S proteasome regulatory subunit 6B

1

2

High-throughput

0.445

High

437997

Q9V434
Asparagine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.445

High

438000

Q9V9Q4
LD43819p

1

1

High-throughput

0.445

High

438001

Q9VAH7
N-terminal kinase-like protein

1

1

High-throughput

0.445

High

438004

IPO9
Importin-9

1

5

High-throughput

0.445

High

438007

Q9VI53
LD44267p

1

2

High-throughput

0.445

High

438017

Q9VW54
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.445

High

438021

MCM7
DNA replication licensing factor Mcm7

1

6

High-throughput

0.445

High

438019

Q9VXR9
FI03680p

1

1

High-throughput

0.439

High

437982

Q0E8E8
Phosphate carrier protein, mitochondrial

1

3

High-throughput

0.437

High

438006

Q9VH62
LD44003p

1

8

High-throughput

0.437

High

262713

TENM
Teneurin-m

1

0

High-throughput

0.426

High

437972

PSMD3
Probable 26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.426

High

437998

Q9V455
Importin subunit alpha

1

0

High-throughput

0.426

High

438010

Q9VQI5
Interferon-related developmental regulator 1

1

0

High-throughput

0.426

High

437994

Q961V9
GH03273p

1

1

High-throughput

0.417

High

438009

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

High-throughput

0.407

High

438016

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.407

High

53664

A1Z843
Nodal modulator 3

2

0

High-throughput

0.298

High

437977

COPB
Coatomer subunit beta

2

0

High-throughput

0.298

High

438015

EXOC7
Exocyst complex component 7

1

0

High-throughput

0.282

High

437985

NETB
Netrin-B

1

0

High-throughput

0.253

Low

84842

B7Z0M0
FI17308p1

1

0

High-throughput

0.251

Low

68870

MBD56
Methyl-CpG-binding domain protein 5/6 homolog sba

1

0

High-throughput

0.249

Low

437971

SRYC
Serendipity locus protein H-1

1

0

High-throughput

0.249

Low

437974

CLH
Clathrin heavy chain

1

0

High-throughput

0.249

Low

437975

GLT
Glutactin

1

0

High-throughput

0.249

Low

437981

CCD1P
Probable cytochrome P450 12d1 proximal, mitochondrial

1

0

High-throughput

0.249

Low

437987

Q76NQ0
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

438002

Q9VAL7
Calnexin 99A, isoform A

1

0

High-throughput

0.249

Low

437993

Q961G6
Cyclin-Q

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025