HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: SRC8 (Q14247)
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Gene: CTTN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16631103
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005884 - actin filament GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 550
+	Hs
		557301 SRC_HUMAN (1-543): 0: 602: 74.22		SRC8_HUMAN (1-550): 0: 561: 100.00
+	Mm
		683098 LYN_MOUSE (1-541): 2.87e-180: 519: 53.14		SRC8_MOUSE (1-550): 0: 550: 92.18
+	Mm
		813506 FYN_MOUSE (1-543): 0: 584: 71.98		HCLS1_MOUSE (1-549): 3.22e-141: 418: 39.71
+	Hs
		486656 FGR_HUMAN (1-542): 0: 564: 67.10		HCLS1_HUMAN (1-550): 2.71e-141: 419: 37.50
+	Mm
		440275 LCK_MOUSE (83-541): 0: 544: 60.78		HCLS1_MOUSE (1-549): 3.22e-141: 418: 39.71
+	Mm
		683090 LYN_MOUSE (1-541): 2.87e-180: 519: 53.14		HCLS1_MOUSE (1-549): 3.22e-141: 418: 39.71
+	Hs
		463307 LYN_HUMAN (1-541): 9.2e-180: 517: 53.69		HCLS1_HUMAN (1-550): 2.71e-141: 419: 37.50
+	Hs
		557075 SRC_HUMAN (1-543): 0: 602: 74.22		PLCG1_HUMAN (212-548): 5.99e-36: 145: 16.53
+	Hs
		440354 FYN_HUMAN (1-543): 0: 584: 72.16		PLCG1_HUMAN (212-548): 5.99e-36: 145: 16.53
+	Hs
		440700 FYN_HUMAN (1-543): 0: 584: 72.16		SH3G2_HUMAN (365-549): 1.88e-31: 126: 17.28
+	Hs
		440701 FYN_HUMAN (1-543): 0: 584: 72.16		SH3G3_HUMAN (365-549): 5.48e-31: 125: 18.82
+	Hs
		463094 YES_HUMAN (1-543): 0: 618: 100.00		LASP1_HUMAN (358-547): 4.31e-13: 71.4: 22.93
+	Hs
		463489 LYN_HUMAN (1-541): 9.2e-180: 517: 53.69		MYO1E_HUMAN (165-549): 9.91e-45: 172: 15.01
+	Hs
		440069 LCK_HUMAN (83-541): 0: 542: 60.78		SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12
+	Hs
		440576 FYN_HUMAN (1-543): 0: 584: 72.16		ITSN1_HUMAN (165-548): 6.15e-15: 80.5: 11.99
+	Hs
		463510 LYN_HUMAN (1-541): 9.2e-180: 517: 53.69		SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12
+	Mm
		683101 LYN_MOUSE (1-541): 2.87e-180: 519: 53.14		DBNL_MOUSE (335-550): 1.4e-31: 128: 29.46
+	Hs
		463538 LYN_HUMAN (1-541): 9.2e-180: 517: 53.69		ITSN1_HUMAN (165-548): 6.15e-15: 80.5: 11.99
+	Hs
		250219 ABL2_HUMAN (9-543): 6.98e-166: 503: 37.96		VINEX_HUMAN (254-546): 4.07e-13: 73.9: 13.51
+	Hs
		320220 ABL2_HUMAN (9-543): 6.98e-166: 503: 37.96		SRBS2_HUMAN (447-549): 1.7e-11: 69.2: 21.91