HitPredict

Interactor 1: TPM2 (P07951)
Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)
Gene: TPM2

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	39358380
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Tropomyosin
Common GO terms	GO:0005829 - cytosol GO:0005884 - actin filament GO:0015629 - actin cytoskeleton
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 284 Hs			1 375
+	Hs
		482868 TPM1_HUMAN (1-284): 1.74e-45: 156: 85.56		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		482879 TPM1_HUMAN (1-284): 1.74e-45: 156: 85.56		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		447727 TPM3_HUMAN (1-284): 5.74e-44: 152: 86.27		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		447734 TPM3_HUMAN (1-284): 5.74e-44: 152: 86.27		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		482881 TPM1_HUMAN (1-284): 1.74e-45: 156: 85.56		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Oc
		946702 TPM1_RABIT (1-284): 1.49e-45: 156: 85.92		ACTS_RABIT (2-375): 0: 592: 93.58
+	Hs
		482876 TPM1_HUMAN (1-284): 1.74e-45: 156: 85.56		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Mm
		946685 TPM1_MOUSE (1-284): 1.49e-45: 156: 85.92		ACTA_MOUSE (2-375): 0: 591: 94.12
+	Hs
		464145 TPM2_HUMAN (1-284): 1.64e-40: 143: 100.00		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Ce
		534407 TPM1_CAEEL (1-282): 4.86e-37: 134: 54.97		ACT4_CAEEL (2-375): 0: 600: 97.59
+	Dm
		482721 TPM2_DROME (1-282): 5.04e-36: 131: 47.52		ACT5_DROME (2-375): 0: 596: 95.99
+	Dm
		482740 TPM2_DROME (1-282): 5.04e-36: 131: 47.52		ACT6_DROME (2-375): 0: 594: 95.99
+	Dm
		387020 TPM2_DROME (1-282): 5.04e-36: 131: 47.52		ACT4_DROME (2-375): 0: 589: 94.65
+	Mm
		953255 TPM4_MOUSE (1-240): 8.61e-15: 74.1: 20.83		ACTB_MOUSE (1-375): 0: 603: 100.00
+	Hs
		952730 TPM4_HUMAN (1-240): 7.77e-14: 71.4: 21.67		ACTB_HUMAN (1-375): 0: 603: 100.00