HitPredict

Interactor 1: TPM1 (P09493)
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
Gene: TPM1

Interactor 2: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Tropomyosin
Common GO terms	GO:0005829 - cytosol GO:0005884 - actin filament GO:0007015 - actin filament organization GO:0015629 - actin cytoskeleton GO:0030017 - sarcomere and 1 others more... GO:0060048 - cardiac muscle contraction
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 284 Hs			1 377
+	Dm
		387020 TPM2_DROME (1-282): 7.78e-35: 128: 49.29		ACT4_DROME (1-377): 0: 649: 92.57
+	Oc
		946702 TPM1_RABIT (1-284): 1.73e-44: 153: 99.65		ACTS_RABIT (1-377): 0: 599: 98.94
+	Hs
		482868 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		482879 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		447727 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		447734 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		482876 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		ACTA_HUMAN (1-377): 0: 597: 98.41
+	Mm
		946685 TPM1_MOUSE (1-284): 1.73e-44: 153: 99.65		ACTA_MOUSE (1-377): 0: 597: 98.41
+	Hs
		464145 TPM2_HUMAN (1-284): 1.4e-38: 138: 85.56		ACTS_HUMAN (1-377): 0: 599: 98.94
+	Hs
		464137 TPM2_HUMAN (1-284): 1.4e-38: 138: 85.56		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Ce
		534407 TPM1_CAEEL (1-282): 3.66e-37: 135: 58.51		ACT4_CAEEL (1-377): 0: 600: 94.43
+	Dm
		482721 TPM2_DROME (1-282): 7.78e-35: 128: 49.29		ACT5_DROME (1-377): 0: 597: 93.10
+	Dm
		482740 TPM2_DROME (1-282): 7.78e-35: 128: 49.29		ACT6_DROME (1-377): 0: 594: 92.84
+	Hs
		952730 TPM4_HUMAN (42-284): 3.78e-33: 123: 68.72		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Mm
		953255 TPM4_MOUSE (1-247): 4.79e-15: 75: 21.86		ACTB_MOUSE (4-377): 0: 598: 94.12