HitPredict

Interactor 1: ACM4 (P08173)
Muscarinic acetylcholine receptor M4
Gene: CHRM4

Interactor 2: CERS6 (Q6ZMG9)
Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291)
Gene: CERS6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 479 Hs			1 384
+	Hs
		630166 ACM3_HUMAN (3-472): 3.59e-89: 285: 40.95		CERS6_HUMAN (1-384): 8.92e-163: 463: 100.00
+	Hs
		1251755 GPR84_HUMAN (50-469): 1.52e-72: 236: 18.87		CERS6_HUMAN (1-384): 8.92e-163: 463: 100.00
+	Hs
		572459 DRD2_HUMAN (3-470): 1.46e-85: 271: 23.86		CERS2_HUMAN (7-342): 1.14e-146: 422: 44.64
+	Hs
		1159070 C3AR_HUMAN (14-462): 2.4e-59: 204: 17.79		CERS6_HUMAN (1-384): 8.92e-163: 463: 100.00
+	Hs
		1159079 C3AR_HUMAN (14-462): 2.4e-59: 204: 17.79		CERS5_HUMAN (6-375): 6.68e-154: 440: 64.96
+	Hs
		1159096 C3AR_HUMAN (14-462): 2.4e-59: 204: 17.79		CERS2_HUMAN (7-342): 1.14e-146: 422: 44.64
+	Hs
		704028 5HT1E_HUMAN (53-228): 6.01e-26: 110: 32.96		CERS6_HUMAN (1-384): 8.92e-163: 463: 100.00
+	Hs
		701424 5HT1B_HUMAN (335-474): 1.26e-33: 132: 29.86		CERS2_HUMAN (7-342): 1.14e-146: 422: 44.64
+	Hs
		704043 5HT1E_HUMAN (53-228): 6.01e-26: 110: 32.96		CERS5_HUMAN (6-375): 6.68e-154: 440: 64.96
+	Hs
		572441 DRD2_HUMAN (3-470): 1.46e-85: 271: 23.86		TRAM1_HUMAN (120-371): 3.29e-69: 224: 19.46
+	Hs
		572412 DRD2_HUMAN (3-470): 1.46e-85: 271: 23.86		CERS1_HUMAN (113-367): 1.15e-60: 200: 33.09
+	Hs
		693400 5HT4R_HUMAN (373-470): 5.78e-29: 119: 29.59		CERS1_HUMAN (113-367): 1.15e-60: 200: 33.09
+	Hs
		704011 5HT1E_HUMAN (53-228): 6.01e-26: 110: 32.96		TRAM2_HUMAN (119-368): 1.33e-62: 206: 19.22
+	Hs
		693388 5HT1E_HUMAN (53-228): 6.01e-26: 110: 32.96		CERS1_HUMAN (113-367): 1.15e-60: 200: 33.09