HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: KRT83 (P78385)
Keratin, type II cuticular Hb3 (Hair keratin K2.10) (Keratin-83) (K83) (Type II hair keratin Hb3) (Type-II keratin Kb23)
Gene: KRT83

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 493
+	Hs
		475752 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C7_HUMAN (27-433): 8.11e-162: 468: 53.30
+	Hs
		407424 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C1_HUMAN (80-436): 1.02e-124: 379: 54.60
+	Hs
		987642 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT81_HUMAN (1-482): 4.2e-113: 345: 95.44
+	Hs
		437141 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C8_HUMAN (83-438): 1.09e-110: 338: 58.15
+	Hs
		227210 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT86_HUMAN (1-486): 2.5e-109: 334: 90.14
+	Hs
		987536 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT85_HUMAN (1-479): 4.43e-100: 311: 81.34
+	Hs
		987749 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C73_HUMAN (2-487): 1.06e-92: 293: 44.27
+	Hs
		987973 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT82_HUMAN (1-492): 1.93e-86: 276: 55.36
+	Hs
		987814 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT35_HUMAN (2-485): 2.92e-79: 256: 24.12
+	Hs
		566356 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C5_HUMAN (4-425): 6.44e-72: 240: 52.59
+	Hs
		385258 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C6A_HUMAN (77-425): 2.66e-70: 235: 58.12
+	Hs
		987641 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K1H2_HUMAN (7-422): 8.96e-66: 220: 23.26
+	Mm
		1133331 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		Q148Q7_MOUSE (24-425): 3.57e-64: 218: 54.73
+	Mm
		1221237 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		Q8BIS2_MOUSE (24-425): 3.22e-64: 218: 54.73
+	Hs
		300561 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT36_HUMAN (23-422): 6.46e-64: 216: 24.94
+	Hs
		473454 HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90		KRT35_HUMAN (2-485): 2.92e-79: 256: 24.12
+	Mm
		431366 SRC_MOUSE (161-215): 3.32e-10: 60.8: 31.58		K2C5_MOUSE (8-425): 1.76e-70: 236: 52.62
+	Hs
		300546 HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90		KRT36_HUMAN (23-422): 6.46e-64: 216: 24.94