HitPredict

Interactor 1: K1C16 (P08779)
Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)
Gene: KRT16

Interactor 2: TCHP (Q9BT92)
Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein)
Gene: TCHP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.663

Property	Details
Experiments	15731013, 32296183, unassigned1304
Identification Methods	pull down, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0045095 - keratin filament
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 473 Hs			1 498
+	Hs
		618097 K1C15_HUMAN (116-429): 2.98e-155: 450: 76.19		TCHP_HUMAN (1-498): 1.02e-59: 206: 100.00
+	Hs
		385161 K1C14_HUMAN (1-448): 4.71e-152: 442: 83.48		TCHP_HUMAN (1-498): 1.02e-59: 206: 100.00
+	Hs
		475678 K1C19_HUMAN (106-434): 2.35e-146: 425: 69.61		TCHP_HUMAN (1-498): 1.02e-59: 206: 100.00
+	Hs
		300482 KRT34_HUMAN (110-437): 1.12e-117: 352: 56.16		TCHP_HUMAN (1-498): 1.02e-59: 206: 100.00
+	Hs
		773163 K1C17_HUMAN (110-445): 1.95e-170: 488: 79.46		MYH10_HUMAN (8-488): 2.29e-11: 68.6: 10.40
+	Hs
		476319 K1C16_HUMAN (1-461): 1.25e-159: 462: 100.00		PLEC_HUMAN (13-496): 5.6e-09: 61.3: 11.81
+	Hs
		385111 K1C14_HUMAN (1-448): 4.71e-152: 442: 83.48		PLEC_HUMAN (13-496): 5.6e-09: 61.3: 11.81
+	Hs
		475580 K1C19_HUMAN (106-434): 2.35e-146: 425: 69.61		PLEC_HUMAN (13-496): 5.6e-09: 61.3: 11.81
+	Hs
		341844 K2C75_HUMAN (1-440): 1.04e-87: 280: 25.11		TCHP_HUMAN (1-498): 1.02e-59: 206: 100.00
+	Hs
		1127796 K1H2_HUMAN (38-437): 2.26e-81: 260: 48.00		TCHP_HUMAN (1-498): 1.02e-59: 206: 100.00
+	Hs
		1367977 KRT35_HUMAN (2-428): 7.83e-81: 259: 49.65		TCHP_HUMAN (1-498): 1.02e-59: 206: 100.00
+	Hs
		1127664 KT33B_HUMAN (67-443): 4.68e-138: 404: 51.19		GG6L2_HUMAN (16-365): 7.76e-09: 60.5: 13.39
+	Hs
		1277622 K1C27_HUMAN (104-435): 7.66e-122: 365: 59.94		CP250_HUMAN (22-497): 3.75e-11: 68.2: 15.21
+	Hs
		300467 KRT34_HUMAN (110-437): 1.12e-117: 352: 56.16		CFA53_HUMAN (141-495): 7.35e-11: 66.3: 14.37
+	Hs
		300358 KRT34_HUMAN (110-437): 1.12e-117: 352: 56.16		PLEC_HUMAN (13-496): 5.6e-09: 61.3: 11.81
+	Hs
		1146104 K1H1_HUMAN (67-452): 6.38e-113: 340: 50.78		CFA53_HUMAN (141-495): 7.35e-11: 66.3: 14.37
+	Hs
		1146051 K1H1_HUMAN (67-452): 6.38e-113: 340: 50.78		GG6L2_HUMAN (16-365): 7.76e-09: 60.5: 13.39
+	Hs
		227225 KRT86_HUMAN (8-428): 1.49e-98: 306: 25.83		PLEC_HUMAN (13-496): 5.6e-09: 61.3: 11.81
+	Hs
		566397 K2C5_HUMAN (82-431): 2.24e-75: 249: 26.14		MRCKA_HUMAN (91-492): 1.24e-26: 116: 12.10
+	Hs
		876475 K2C6C_HUMAN (18-447): 1.51e-76: 251: 25.00		PLEC_HUMAN (13-496): 5.6e-09: 61.3: 11.81