HitPredict

Interactor 1: A0A8V8TNS8 (A0A8V8TNS8)
SH3 domain-containing kinase-binding protein 1
Gene: SH3KBP1

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 427 Hs			1 906
+	Hs
		651470 CD2AP_HUMAN (1-409): 1.44e-59: 207: 38.33		CBL_HUMAN (1-906): 0: 882: 100.00
+	Mm
		651582 CD2AP_MOUSE (1-409): 3.6e-60: 208: 38.33		CBL_MOUSE (1-906): 0: 851: 91.59
+	Hs
		593911 NCK1_HUMAN (102-403): 4.46e-31: 124: 14.94		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		222020 NCK2_HUMAN (103-403): 5.8e-27: 113: 15.15		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		1097965 CD2AP_HUMAN (1-409): 1.44e-59: 207: 38.33		CBLB_HUMAN (23-901): 0: 767: 47.02
+	Mm
		651564 NCK1_MOUSE (102-403): 9.84e-31: 123: 15.24		CBL_MOUSE (1-906): 0: 851: 91.59
+	Mm
		651529 GRB2_MOUSE (2-158): 5.04e-24: 101: 18.06		CBL_MOUSE (1-906): 0: 851: 91.59
+	Rn
		93096 GRB2_RAT (2-158): 9.95e-24: 100: 17.59		D3ZV15_RAT (1-884): 0: 802: 88.90
+	Mm
		86325 NCK1_MOUSE (102-403): 9.84e-31: 123: 15.24		B9EKI5_MOUSE (23-901): 0: 775: 47.66
+	Hs
		593984 NCK1_HUMAN (102-403): 4.46e-31: 124: 14.94		CBLB_HUMAN (23-901): 0: 767: 47.02
+	Hs
		222074 NCK2_HUMAN (103-403): 5.8e-27: 113: 15.15		CBLB_HUMAN (23-901): 0: 767: 47.02
+	Mm
		237074 NCK2_MOUSE (103-403): 7.64e-27: 112: 14.55		CBLB_MOUSE (23-901): 0: 764: 46.56
+	Mm
		86322 GRB2_MOUSE (2-158): 5.04e-24: 101: 18.06		B9EKI5_MOUSE (23-901): 0: 775: 47.66
+	Mm
		1189573 GRB2_MOUSE (2-158): 5.04e-24: 101: 18.06		CBLB_MOUSE (23-901): 0: 764: 46.56
+	Hs
		1461779 CD2AP_HUMAN (1-409): 1.44e-59: 207: 38.33		CBLC_HUMAN (42-500): 0: 600: 43.13
+	Ce
		711462 SEM5_CAEEL (2-167): 1.31e-27: 111: 19.28		Q6ABG8_CAEEL (43-510): 0: 677: 48.24
+	Ce
		711455 SEM5_CAEEL (2-167): 1.31e-27: 111: 19.28		Q19019_CAEEL (49-559): 0: 658: 42.26
+	Hs
		1273877 CD2AP_HUMAN (1-409): 1.44e-59: 207: 38.33		MICA3_HUMAN (455-888): 8.25e-10: 65: 11.70
+	Hs
		215903 NCK1_HUMAN (102-403): 4.46e-31: 124: 14.94		SYNJ1_HUMAN (391-793): 3.14e-10: 66.5: 11.84
+	Hs
		1251268 DNMBP_HUMAN (4-372): 1.38e-27: 118: 19.27		PTN23_HUMAN (428-857): 1.99e-09: 63.8: 8.37