HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11748221
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 197
+	Hs
		481249 HMGB1_HUMAN (1-174): 9.5e-45: 150: 100.00		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Mm
		991151 HMGB1_MOUSE (1-174): 9.5e-45: 150: 100.00		TLE1_MOUSE (2-197): 2.16e-101: 310: 63.00
+	Hs
		1047858 SOX7_HUMAN (65-181): 1.31e-28: 112: 19.66		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Mm
		988922 HMGB1_MOUSE (1-174): 9.5e-45: 150: 100.00		TLE5_MOUSE (1-197): 2.67e-101: 292: 99.49
+	Hs
		872234 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		1048081 SOX7_HUMAN (65-181): 1.31e-28: 112: 19.66		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		1047865 SOX17_HUMAN (7-90): 3.94e-22: 94.8: 19.05		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		942092 SOX10_HUMAN (4-98): 2.08e-21: 93.2: 14.74		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		872235 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		190010 TOX3_HUMAN (91-165): 4.67e-29: 115: 40.00		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		604642 UBF1_HUMAN (10-158): 4.17e-09: 57.8: 23.60		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		872247 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		1061877 SOX17_HUMAN (7-90): 3.94e-22: 94.8: 19.05		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		1048069 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Dm
		594689 DICH_DROME (7-101): 9.28e-27: 107: 24.21		GROU_DROME (2-163): 3.56e-59: 198: 54.44