HitPredict

Interactor 1: TLE5 (P63002)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG)
Gene: TLE5

Interactor 2: HMGB1 (P63158)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	11748221
Identification Methods	pull down, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 197 Mm			1 215
+	Hs
		481249 TLE1_HUMAN (2-197): 2.34e-109: 331: 64.50		HMGB1_HUMAN (1-174): 1.02e-41: 142: 100.00
+	Mm
		991151 TLE1_MOUSE (2-197): 2.24e-98: 302: 63.00		HMGB1_MOUSE (1-174): 1.02e-41: 142: 100.00
+	Hs
		1048069 TLE3_HUMAN (2-197): 1.05e-105: 322: 61.00		CIC_HUMAN (57-210): 2.52e-30: 119: 19.48
+	Hs
		481256 TLE5_HUMAN (1-197): 2.88e-103: 297: 99.49		HMGB1_HUMAN (1-174): 1.02e-41: 142: 100.00
+	Hs
		872234 TLE1_HUMAN (2-197): 2.34e-109: 331: 64.50		SOX2_HUMAN (3-94): 1.6e-22: 94.8: 23.91
+	Hs
		1047865 TLE1_HUMAN (2-197): 2.34e-109: 331: 64.50		SOX17_HUMAN (7-90): 1.16e-20: 90.6: 19.05
+	Hs
		942092 TLE1_HUMAN (2-197): 2.34e-109: 331: 64.50		SOX10_HUMAN (4-98): 3.16e-20: 89.8: 14.74
+	Hs
		872235 TLE3_HUMAN (2-197): 1.05e-105: 322: 61.00		SOX2_HUMAN (3-94): 1.6e-22: 94.8: 23.91
+	Hs
		190010 TLE5_HUMAN (1-197): 2.88e-103: 297: 99.49		TOX3_HUMAN (91-165): 2.48e-29: 116: 40.00
+	Hs
		1047858 TLE1_HUMAN (2-197): 2.34e-109: 331: 64.50		SOX7_HUMAN (3-90): 3.84e-13: 69: 19.32
+	Hs
		872247 TLE5_HUMAN (1-197): 2.88e-103: 297: 99.49		SOX2_HUMAN (3-94): 1.6e-22: 94.8: 23.91
+	Hs
		604642 TLE1_HUMAN (2-197): 2.34e-109: 331: 64.50		UBF1_HUMAN (10-158): 4.12e-10: 60.5: 23.60
+	Hs
		1048081 TLE3_HUMAN (2-197): 1.05e-105: 322: 61.00		SOX7_HUMAN (3-90): 3.84e-13: 69: 19.32
+	Hs
		1061877 TLE5_HUMAN (1-197): 2.88e-103: 297: 99.49		SOX17_HUMAN (7-90): 1.16e-20: 90.6: 19.05
+	Dm
		594689 GROU_DROME (2-163): 8.15e-60: 200: 54.44		DICH_DROME (8-101): 9.22e-25: 101: 24.47