HitPredict

Interactor 1: HMGB1 (P63158)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: TLE1 (Q62440)
Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg-1)
Gene: TLE1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	11748221
Identification Methods	pull down, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Mm			1 770
+	Hs
		481249 HMGB1_HUMAN (1-174): 1.02e-41: 142: 100.00		TLE1_HUMAN (1-770): 0: 590: 97.15
+	Hs
		1048069 CIC_HUMAN (57-210): 2.52e-30: 119: 19.48		TLE3_HUMAN (1-770): 3.96e-176: 526: 77.55
+	Dm
		594689 DICH_DROME (8-101): 9.22e-25: 101: 24.47		GROU_DROME (1-770): 3.13e-140: 432: 59.41
+	Hs
		481256 HMGB1_HUMAN (1-174): 1.02e-41: 142: 100.00		TLE5_HUMAN (1-200): 3.9e-89: 280: 64.00
+	Mm
		988922 HMGB1_MOUSE (1-174): 1.02e-41: 142: 100.00		TLE5_MOUSE (1-200): 3.29e-89: 280: 64.00
+	Hs
		190010 TOX3_HUMAN (91-165): 2.48e-29: 116: 40.00		TLE5_HUMAN (1-200): 3.9e-89: 280: 64.00
+	Hs
		261400 SSRP1_HUMAN (53-164): 9.75e-28: 111: 37.50		TBL1X_HUMAN (164-729): 3.27e-82: 275: 11.36
+	Hs
		1065414 SSRP1_HUMAN (53-164): 9.75e-28: 111: 37.50		TBL1R_HUMAN (245-729): 5.19e-81: 270: 12.45
+	Hs
		261381 SOX2_HUMAN (3-94): 1.6e-22: 94.8: 23.91		TBL1X_HUMAN (164-729): 3.27e-82: 275: 11.36
+	Hs
		1065344 SSRP1_HUMAN (53-164): 9.75e-28: 111: 37.50		FBXW7_HUMAN (410-680): 6.86e-49: 185: 13.48
+	Hs
		481188 HMGB1_HUMAN (1-174): 1.02e-41: 142: 100.00		WDR5_HUMAN (275-601): 4.96e-36: 141: 11.98
+	Hs
		687182 HMGB2_HUMAN (1-187): 5.71e-40: 137: 82.89		WDR5_HUMAN (275-601): 4.96e-36: 141: 11.98
+	Hs
		964850 TFAM_HUMAN (9-189): 1.33e-32: 119: 20.79		WDR5_HUMAN (275-601): 4.96e-36: 141: 11.98
+	Hs
		965173 CIC_HUMAN (57-210): 2.52e-30: 119: 19.48		WDR5_HUMAN (275-601): 4.96e-36: 141: 11.98
+	Hs
		964889 SSRP1_HUMAN (53-164): 9.75e-28: 111: 37.50		WDR5_HUMAN (275-601): 4.96e-36: 141: 11.98
+	Hs
		872148 SOX2_HUMAN (3-94): 1.6e-22: 94.8: 23.91		WDR5_HUMAN (275-601): 4.96e-36: 141: 11.98
+	Hs
		1065355 SSRP1_HUMAN (53-164): 9.75e-28: 111: 37.50		SNR40_HUMAN (472-642): 1.97e-27: 116: 18.54
+	Hs
		1065463 SSRP1_HUMAN (53-164): 9.75e-28: 111: 37.50		NLE1_HUMAN (688-767): 2.43e-21: 100: 22.22
+	Hs
		209254 SSRP1_HUMAN (53-164): 9.75e-28: 111: 37.50		PRP4_HUMAN (535-761): 1.05e-11: 70.1: 26.92
+	Hs
		209215 SOX2_HUMAN (3-94): 1.6e-22: 94.8: 23.91		PRP4_HUMAN (535-761): 1.05e-11: 70.1: 26.92