HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: RC3H2 (Q9HBD1)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
Gene: RC3H2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29395067, 23663784
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0010494 - cytoplasmic stress granule GO:0016020 - membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 1191
+	Hs
		1329984 PABP3_HUMAN (1-636): 0: 541: 91.37		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1031467 PABP4_HUMAN (1-635): 0: 534: 74.69		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		516550 PABP1_HUMAN (1-636): 0: 582: 100.00		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136287 PABP3_HUMAN (1-636): 0: 541: 91.37		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1031360 PABP4_HUMAN (1-635): 0: 534: 74.69		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		680490 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1288632 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		582503 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1136223 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		582333 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		516595 PABP1_HUMAN (1-636): 0: 582: 100.00		KMT2C_HUMAN (351-895): 4.49e-14: 79.7: 9.35
+	Hs
		582292 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		MDC1_HUMAN (442-806): 1.14e-11: 71.8: 12.21
+	Hs
		582417 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		PRG4_HUMAN (469-824): 3.07e-09: 63.7: 13.04