HitPredict

Interactor 1: BMP2 (P12643)
Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
Gene: BMP2

Interactor 2: BMPR2 (Q13873)
Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
Gene: BMPR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.960

The method score is based on:

Property Details
Experiments 7791754, 10880444, 10712517, 24337809, 25938661, 18342887, 17295905
Identification Methods affinity chromatography technology, pull down, surface plasmon resonance
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~TGF_beta
Common GO terms GO:0001649 - osteoblast differentiation
GO:0003176 - aortic valve development
GO:0005615 - extracellular space
GO:0009986 - cell surface
GO:0010628 - positive regulation of gene expression
and 10 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 396
Hs

1 1038
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024